Curriculum Vitae

Dr. Yan Li

July 26, 2022

General Information

University address:	Chemical and Biomedical Engineering
FAMU-FSU College of Engineering
2525 Pottsdamer Street, B343
Florida State University
Tallahassee, Florida 32310-6046
Phone: (850) 410-6320; Fax: (850) 410-6150

E-mail address:	yli@eng.famu.fsu.edu
	yli@eng.famu.fsu.edu; yli4@fsu.edu; yan.li@famu.edu

Web site:	http://www.eng.fsu.edu/faculty/cbe/li.html.   (H-factor 38; OCRID: 0000-0002-5938-8519)

Professional Preparation

2002	Ph.D., The Ohio State University, Columbus, OH. Major: Chemical Engineering. 

Yan Li. (2002). Human tissue development in three-dimensional nonwoven fibrous matrix with defined microstructure. Unpublished doctoral dissertation, The Ohio State University, Columbus, OH. 

1995	B.S., Tsinghua University, Beijing, P.R. China. Major: Chemical Engineering. Graduated with honors. 

Professional Experience

2022–present	Affiliates, Brain Science and Symptom Management Center (BSSMC), Florida State University. 

2022–present	Adjunct Professor, Auburn University. 

2018–present	Associate Professor, Chemical and Biomedical Engineering Department, FAMU-FSU College of Engineering, Florida State University. Research area includes: stem cell technology and engineering, biomaterials and three-dimensional multicellular structure.

2015–present	Affiliates, National High Magnetic Field Laboratory, Florida State University. 

2013–present	Affiliates, Institute for Successful Longevity, Florida State University. 

2013–present	Institute of Molecular Biophysics Graduate Faculty, Florida State University. 

2011–2018	Assistant Professor, Chemical and Biomedical Engineering Department, FAMU-FSU College of Engineering, Florida State University. 

2009–2011	Principal Scientist, Group/Project leader, Department of Process Sciences, Geron Corporation, Menlo Park, California. Supervised the activity of Process Sciences and led the joint process development efforts for human pluripotent embryonic stem cell (hPSC)-derived products among Process Sciences, Manufacturing Operations, and Manufacturing Sciences.

2007–2009	Senior Scientist, Department of Process Sciences, Geron Corporation, Menlo Park, California. Responsible for process development and technology transfer of human pluripotent stem cell-derived cell products, including oligodendrocyte progenitor cells, cardiomyocytes, and dendritic cells.

2003–2006	Scientist II, Department of Process Sciences, Geron Corporation, Menlo Park, California. Responsible for optimization and scale-up of undifferentiated human embryonic stem cell culture process, oligodendrocyte progenitor cell differentiation process, cardiomyocyte differentiation process, peripheral blood mononuclear cell-derived dendritic cells.

2002–2003	Scientist, Department of Product Development, Geron Corporation, Menlo Park, California. Responsible for process development of human embryonic stem cell culture system.

Honors, Awards, and Prizes

Developing Scholar Award, Florida State University (2021). ($10,000). 
Top 100 papers, Scientific Reports (2020). 
Innovator award, Florida State University (2019). 
Nominated for Research Award, College of Engineering, Florida State University (2019). 
NSF CAREER award, NSF (2017). 
Cell Culture Engineering XV Organizer, ECI (2016). 
Innovator award, Florida State University (2013). 
Exceptional speaker award, Society for Biological Engineering (2012). 
First Year Assistant Professor Award, Florida State University (2012). 
Geronosity Award (for GRNCM1 process lock down), Geron Corporation (2010). 
Award for GE HealthCare Technology Transfer, Geron Corporation (2009). 
Award of Achievement for GRNOPC1 program, Geron Corporation (2008). 
Geronosity Award (for cadiomyocyte culture and recombinant laminin-1), Geron Corporation (2006). 
Outstanding Graduate Award for Academic Achievement, The Ohio State University (2001). 
CIC Women in Science and Engineering Travel Award, The Ohio State University (2000). 
Graduate Student Alumni Research Award, The Ohio State University (2000). 
129 Scholarship, Tsinghua University (1994). 
Guanghua Scholarship, Tsinghua University (1993). 

Fellowship(s)

Presidential Fellowship, The Ohio State University (2001).
Department Fellowship, The Ohio State University (1999–2000).
University Fellowship, The Ohio State University (1997–1998).

Current Membership in Professional Organizations

American Chemical Society (ACS) 
American Institute of Chemical Engineers (AIChE) 
Biomedical Engineering Society (BMES) 
International Society for Experimental Hematology (ISEH) (2001) 
International Society for Extracellular Vesicles (ISEV) 
International Society for Stem Cell Research (ISSCR) 
Phi Kappa Phi, National Honor Society 
Society for Biological Engineering (SBE) 

Teaching

Courses Taught

BiotransportPhenomena, four times (BME3361)
Neural Engineering, three times (BME4937)
Biomedical Engineering, four times (BME4007)
Dissertation (Biomedical Engineering) (BME6980)
Dissertation (Chemical Engineering) (ECH6980)
Doctoral Preliminary Examination (BME8965)
Thesis (Chemical Engineering) (ECH5971)
Thesis Defense (Biomedical Engineering) (BME8976)
Honors URP in Biomedical Engineering, >ten times (BME4906)
Dissertation Defense (Biomedical Engineering) (BME8985)
Doctoral Preliminary Examination, four times (ECH8965)
Thesis (Biomedical Engineering) (BME5971)
Bioengineering, three times (ECH4743)
Special Topics in Chemical Engineering, twice (ECH5934)
Dissertation Defense (Chemical Engineering) (ECH8985)
Introduction to Biomedical Engineering (BME3009)
Special Topics: Cellular and Tissue Engineering, twice (BME 5937)
Biomedical Engineering Seminar, three times (BME5935)
Chemical Engineering Seminar, three times (ECH5935)
URP- StemCell Eng (BME4904)
Honors URP in Chemical Engineering (ECH4906)
Mass and Energy Balances II, twice (ECH3024)
Thesis Defense (Chemical Engineering) (ECH8976)
Mass and Energy Balances I, three times (ECH3023)

Curriculum Development

Biomedical Engineering new BS degree, syllabi revision, teaching lab instrument acquisition and set up (2019)
BME4937-BME3361, Biotransport Phenomena, Fall 2019. A new course that is offered the first time to the first cohort of junior undergraduate students who will receive B.S. in Biomedical Engineering (2019)
In Bioengineering and Biomedical Engineering, incorporation of the topics of current Good Manufacturing Practices (cGMP), quality by design, and Pharmaceutical Engineering (2012)

Doctoral Committee Chair

Jeske, R., graduate. (2022). Bioreactor Regulation of Human Mesenchymal Stem Cell Metabolism, Homeostasis, and Extracellular Vesicle Biogenesis.  [with NSF-sponsored Internship. Mission Barns Inc]
Marzano, M., graduate. (2021). Modeling the interactions of extracellular vesicles with vascular cells based on human pluripotent stem cells.  [OrganaBio]
Bejoy, J., graduate. (2019). Modelling Brain Tissue Patterning of Human Pluripotent Stem Cells Using Cell Signaling Modulation.  [A postdoc at Vanderbilt University]
Song, L., graduate. (2018). Modelling 3-D Brain-like Tissues using human Stem Cell-Derived Vascular spheroids, Cortical Spheroids, and Microglia-like cells.  [A postdoc at Carnegie-Mellon University]
Yan, Y., graduate. (2017). Engineering neural tissue pattering of human induced pluripotent stem cells for modeling Alzheimer's disease.  [A postdoc at University of Wisconsin-Madison]
Esmonde, C., doctoral student.  Multifunctional 3D Bioelectronic and Microfluidic Hybrid Systems for Monitoring and Vascularization of Brain Organoids. 
Justice, E., doctoral student.  Biomaterials and extracellular vesicle interactions in 3D human stem cell models. 
Liu, C., doctoral student.  Engineering human stem cell-derived extracellular matrices and vesicles.  [with NSF-sponsored Internship]
Muok, L., doctoral student.  Human stem cell-biomaterials interactions.  [with McKnight Fellowship and NSF internship]
Chen, X., doctoral student.  Biophysical regulation of human stem cells through novel biomaterials. 

Doctoral Committee Cochair

Hua, T., graduate. (2022). Cerebellum organoid engineering from hPSCs for medullablastoma modeling and drug screening.  [A postdoc at Emory University]
Xue, Y., doctoral student.  Brain tumor models. 
Berry, D., doctoral student.  Studying cell-biomaterials interactions and neuroinflammation. 
McDaniel, G., doctoral student.  MiRNA engineering of human brain organoid-derived extracellular vesicles.  [with College of Engineering Dean's Fellowship]
Roy, A., doctoral student.  Engineering human mesenchymal stem cells and extracellular vesicles. 
Kiran, S., doctoral student.  The influence of microplastics on human stem cell-derived brain spheroids. 

Doctoral Committee Member

Helsper, S., graduate. (2022). Efficacy of stem cell-derived therapy for ischemic stroke: a multi-nuclear MR toolbox (NIH F31 Fellow) (co-sponsored). 
Holder, S., graduate. (2022). MR imaging and spectroscopy to evaluate the impacts of estrogen during acute migraine. 
Hike, D., graduate. (2021). Diffusion Tensor Imaging-based Network Analysis of Rodent Brains in the Monitoring of Disease Progression and Treatment Efficacy. 
Abad, N., graduate. (2019). Accute NTG Triggered Migraine: Evaluating the Holy Trinity in Neurological Disorders. 
Bijonowski, B., graduate. (2019). Cellular Stress Response Induced by Aggregation in Mesenchymal Stem Cells Activates Cellular Rejuvenation Pathways. 
Ogden, S., graduate. (2019). Modeling ZIKA virus infection and pathogenesis in neuroglia and 3D cerebral organoids (Department of Biological Science). 
Yuan, X., graduate. (2019). Metabolism and redox cycle in human mesenchymal stem cells with culture induced senescence: homeostasis and rejuvenation. 
Hammack, C., graduate. (2018). Zika virus infection induces DNA damage response and S-phase arrest in human cortical neural progenitors leading to their attenuated growth (Department of Biological Science). 
Liu, Y., graduate. (2016). Metabolic regulation of human mesenchymal stem cells for cell therapy. 
Tsai, Ang-Chen, graduate. (2016). In Vitro Expansion and Functional Enhancement of Human Mesenchymal Stem Cell in Cell Therapy. 
Xia, J., graduate. (2016). Top-down fabrication of microdevices and micropatterns for cell-borne drug delivery, biosensing and cell-tracking. 
Bosco, D., graduate. (2015). Influencing human mesenchymal stem cell behavior with small molecular compounds (Institute of Molecular Biophysics). 
Leonard, S., graduate. (2014). Solid State NMR Structural Analysis OF Designer Self-Assembling Peptides MAX8 and SAF. 
Bhagu, J., doctoral candidate.  MRI analysis of stroke therapy by human stem-cell derived extracellular vesicles. 
Naha, A., doctoral candidate.  Integrin dependent inflammatory responses. 
Sadeghifar, A., doctoral candidate.  Cellular Biomechanics. 
Li, G., doctoral candidate.  The encapsulation of pharmaceutical drug during polymerization induced self-assembly (PISA) (Dr. Ralm Ricarte). 
Liu, Y., doctoral candidate.  Bone regeneration capacity of extracellular vesicles isolated from bone marrow and adipose tissue derived from mesenchymal stem cells. 
Cheng, W., doctoral candidate.  Exploring drug-delivery potential of microparticles fabricated via micro-contact-printing. 
Wang, J., doctoral student.  Pharmacological model of Alzheimer's disease. 

Doctoral Committee University Representative

Medina, A., graduate. (2022). Zika virus infection and stem cell blood brain barrier model. 
Zhang, J., graduate. (2022). Studying a poly-synaptic neural pathway underling psychosis-like behavior in mice. 
Lee, J., doctoral candidate.  Brain cancer models based on human stem cell-derived brain organoids. 
Navarrete, M., doctoral candidate.  Brain neurophysiology in neurological disorders. 
Qi, L., doctoral candidate.  Degradation fate and transport of environmental contaminants. 

Master's Committee Chair

Muok, L., graduate. (2022). Engineering Human Pluripotent Stem Cell-derived Choroid Plexus Organoids. 
Griffin, K., graduate. (2019). Engineering stem cell-derived multicellular aggregates of glial cells. 
Marzano, M., graduate. (2019). Differential Effects of Extracellular Vesicles of Lineage-specific Human Pluripotent Stem Cells on Cellular Behaviors of Isogenic Cortical Spheroids. 
Bejoy, J., graduate. (2016). Biological relevance of YAP regulation by Wnt signaling during neural differentiation of human induced pluripotent stem cells. 
Song, L., graduate. (2015). PCL-PDMS-PCL microspheres mediate cardiovascular differentiation of pluripotent stem cells. 
Yan, Y., graduate. (2014). MPIO labeling of Pluripotent Stem Cell-derived Neural Progenitors. 

Master's Committee Member

Chen, S., graduate. (2019). Lignin-based biodegradable aliphatic polyester. 
Lewis, S., graduate. (2019). Shear Stress Modulates Human Mesenchymal Stem Cells (hMSCs) Immune Response. 
Hike, D., graduate. (2018). DTI-based connectivity analysis of APP/PS1 mouse brains. 
Abad, N., graduate. (2016). Quantitative Analysis Of Sodium Flues And Metabolic Changes In Migraine Using 23NA MRI And 1H MRS At Ultra High Field. 
Ould Ismail, A. A., graduate. (2016). DTI-based Connectivity in Isolated Neural Ganglia: A Default Structural Graph in a Small World Framework. 
Naha, A., student.  Integrin dependent inflammatory responses in cells of the intervertebral disc. 
Sadeghifar, A., student.  Cell mechanosensing field with a focus on Arp2/3 nhibition and actin branching. 

Bachelor's Committee Chair

Jean-Baptiste, C., graduate. (2022). Study of human stem cell-derived exosomes as drug delivery vehicles. 
Sears, K., graduate. (2022). Engineering brain organoids from human stem cells for drug screening. 
Canónicco Castro, M. L., graduate. (2021). Engineering Human Stem Cells in a Novel Vertical Wheel Bioreactor. 
Sanders, K., graduate. (2020). Honors URP: Computational Modeling of Shear Stress in a Microcarrier-based Spinner Flask Bioreactor. 
Griffin, K., graduate. (2017). URP Thesis: Effect of Specific Extracellular Matrix Components on the Behavior of Mesenchymal Stem Cell-Human Induced Pluripotent Stem Cell Co-cultured Spheroids. 
Madinya, J., graduate. (2016). Honors URP thesis: Evaluating Hydrodynamics and Mass Transfer in Spinner-Flask Bioreactor for Culturing of Human Cortical Spheroids (2017 NSF Graduate Research Fellow, UIUC). 
Nicholson, C., graduate. (2016). Honors URP thesis: Studying Induced Pluripotent Stem Cell Differentiation into Glutamatergic Neurons and Alzheimer's Disease Models. 
Greist, C., graduate. (2015). URP research: Extracellular proteins of multicellular pluripotent stem cell aggregates. 
Harris, D., graduate. (2013). FAMU Title III project: Neural Differentiation of Pluripotent Stem Cells. 
Gonzalez, V., student.  Hydrogel encapsulation and controlled release of human stem cell-derived extracellular vesicles. 
McGarraugh, C., student.  Engineering human stem cell-derived exosomes. 

Bachelor's Committee Member

Al-Humiari, A., graduate. (2022). Semi-automatic system selup regarding cavitation rheology measursements for direct applications in traumatic brain injury. 
Lynch, K., graduate. (2021). Cartilage production and the use of stem cells to repair cartilage (Department of Biological Sciences). 
Hall, E., graduate. (2017). Fabrication of Avidin-Based Microdevices Using Unmodified Poly(dimethylsiloxane): A Platform for Drug Delivery. 
Padgett, K., graduate. (2014). Fabrication of binder-free electrodes. 

Supervision of Student Research Not Related to Thesis or Dissertation

50% trainees went to graduate or medical schools (2012–present). 

Boirie, B. (2022–24). 

Nathani, A. (2022–24). 

Espinoza, Freydell (Supported by NSF REU) (2022–23). 

Arthur, P. (2020–23). 

Zeng, O. (Jun–Dec 2022). 

Zeng, E. (Jun 2021–Dec 2022). 

Wang, J. (Jul–Aug 2022). 

Lee, R. (Jun–Aug 2022). 

Liang, A. (Jun–Aug 2022). 

Martinez, K. (May–Aug 2022). 

Leng, A. (Jun–Jul 2022). 

Meng, D. (Jun–Jul 2022). 

Wei, Joy-Ann (Jun–Jul 2022). 

Wei, V. (Jun–Jul 2022). 

Frost, Haddie (sponsored by WIMSE) (Dec 2021–Jun 2022). 

Ma, S. (Jun–Dec 2021). 

Compagno, M. (Sep–Nov 2021). 

Guy, L. (May–Oct 2021). 

Chen, W. (Jun–Jul 2021). 

Johnson, C. (Jan–Apr 2021). 

Kutlehria, S. (Aug 2019–Jul 2020). 

Albo, Jonathan (2020 NSF Graduate Research Fellow) (Aug 2019–Apr 2020). 

Yaeger, N. (Jul 2019–Mar 2020). 

Bou-Dargham, M. (Sep 2018–Aug 2019). 

Wang, J. (Jun–Jul 2019). 

Haldiya, T. (Jun 2019). 

Patel, D. (May–Dec 2018). 

Touza, M. (May–Aug 2018). 

Wang, Z. (Sep 2017–May 2018). 

Paez, J. (Jul–Sep 2017). 

Griffin, K. (May 2016–May 2017). 

Sahwell, P. (May 2015–Jul 2016). 

Perron, R. (Apr–Jun 2016). 

Lucas, S. (Sep 2015–Apr 2016). 

Madinya, J. (Aug 2015–Apr 2016). 

Nicholson, C. (Apr 2015–Apr 2016). 

Greist, C. (Jul 2013–Dec 2014). 

Felix, D. (Jun 2013–Jun 2014). 

Martin, L. (Jul–Aug 2013). 

Wang, J. (Jun–Aug 2013). 

Bridges, S. (Nov 2012–Jan 2013). 

Rotterman, Y. (2013). 

Harris, D. A. (2012). 

Additional Teaching Not Reported Elsewhere

Li, Y. (2001). ChE766: Biotechnology and Bioprocess Engineering. Gave lecture when the instructor was absent. The Ohio State University. 

Li, Y. (2001). Teaching assistant of ChE523: Chemical Engineering Operations. Gave lecture when the instructor was absent. The Ohio State University. 

Li, Y. (2000). Teaching assistant of ChE523: Chemical Engineering Operations. The Ohio State University. 

Li, Y. (1999). Teaching assistant of ChE762: Chemical Engineering Process Development. Led the project for one group (5 undergraduate students). The Ohio State University. 

Training

Li, Y. (2010). Training 2 scientists from University of Washington. 

Li, Y. (2010). Training, advising, and transferring technology for 3 scientists from Lonza as company's technical leader. 

Li, Y. (2009). Training 3 scientists from University of California at Santa Barbara. 

Li, Y. (2009). Training, advising, and transferring technology for 3 scientists from GE Healthcare as company's technical leader (UK). 

Li, Y. (2008). Training 2 scientists from Corning Life Sciences. 

Li, Y. (2005–2007). Training and advising 1 Ph.D. Student and 1 Post-doc from University of California at Berkeley about hESC culture and characterization. 

Li, Y. (2003–2004). Training 2 scientists from Roslin Institute (UK). 

Li, Y. (2002–2003). Training 4 scientists from University of California at San Francisco (UCSF). 

Research and Original Creative Work

Dr. Li's research mainly focuses on pluripotent stem cell expansion and differentiation, tissue engineering, and biomaterials. Based on her 9-year experience at Geron Corporation, the world leader in human pluripotent stem cell technology, Dr. Li is interested in developing a research program focused on stem cell-based systems for drug screening, disease modeling, and regenerative medicine. Specifically, her research focuses on the 3-D multicellular stem cell culture systems, the extracellular matrix, and other cell-biomaterials interactions, cell-cell interactions (such as extracellular vesicles), and signaling pathways (such as the Wnt pathway, Hippo/YAP pathway, and Notch pathway). Some research projects are collaborative (such as nanogratings, auxetic scaffolds, and hydrogel study), indicating her expertise in stem cell engineering. The funded research by NSF, NIH, and Florida DOH include engineering brain region-specific organoids, engineering extracellular matrix during neural degeneration, stem cell-based brain tumour organoid model, and heterotypic cell-cell interactions (neurovascular unit, neural-microglia).  The PI has a total of 100+ publications, 4800+ citations, an H-factor: 38.  ORCID: 0000-0002-5938-8519.  * indicates corresponding author.
https://www.ncbi.nlm.nih.gov/myncbi/1jyYtw7ZnLDkc/bibliography/public/
https://scholar.google.com/citations?user=hHCTRMgAAAAJ&hl=en.

Publications

Invited Journal Articles

Yuan, X., Chen, X., Zeng, C., Meckes, D., & *Li, Y. (2022). Extracellular Vesicle Collection from Human Stem Cells Grown in Suspension Bioreactors. Methods in Molecular Biology, 2436, 193-204. doi:10.1007/7651_2021_416

Chen, X., Liu, C., Muok, L., Zeng, C., & Li, Y. (2021). Dynamic 3D On-chip BBB Model Design, Development, and Applications in Neurological Diseases. Cells, 10, 3183.

Sart, S., Liu, C., Zeng, E., Xu, C., & *Li, Y. (2021). Downstream bioprocessing of human pluripotent stem cell-derived therapeutics. Engineering in Life Sciences, 00, 1-14.

*Sart, S., Yuan, X., Jeske, R., & *Li, Y. (2021). Engineering Exosomal microRNAs in Human Pluripotent Stem Cells. Advances in Stem Cell Biology, 12, 1-12.

Tsai, A.-C., Jeske, R., Chen, X., *Yuan, X., & *Li, Y. (2020). Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers. Frontiers in Bioengineering and Biotechnology, 8, 640-660.

Song, L., Yan, Y., Marzano, M., & *Li, Y. (2019). Studying heterotypic cell-cell interactions in human brain using pluripotent stem cell models for neurodegeneration. Cells, 8, 299-323.

Yan, Y. #., Bejoy, J. #., Marzano, M., & *Li, Y. (2019). The use of pluripotent stem cell-derived organoids to study extracellular matrix development during neural degeneration. Cells, 8, 242-272.

*Sart, S., Bejoy, J., & *Li, Y. (2017). Characterization of 3D pluripotent stem cell aggregates and the impact of their properties on bioprocessing. [Invitation to S Sart and Y Li]. Process Biochemistry, 59, 276-288.

Yan, Y., Song, L., Tsai, A.-C., Ma, T., & *Li, Y. (2016). Generation of Neural Progenitor Spheres from Human Pluripotent Stem Cells in a Suspension Bioreactor [Invitation to Y Li]. Methods in Molecular Biology, 1502, 119-128.

Bejoy, J., Song, L., & *Li, Y. (2016). Wnt-YAP Interactions in the Neural Fate of Human Pluripotent Stem Cells and the Implications for Neural Organoid Formation [Invitation to Y Li]. Organogenesis, 12, 1-15.

Sart, S., Song, L., & *Li, Y. (2015). Controlling Redox Status for Stem Cell Survival, Expansion and Differentiation [Invitation to Y Li]. Oxidative Medicine and Cellular Longevity: Special Issue "Reactive Oxygen Species in Stem Cells", 105135, 1-14.

Sart, S., Calixto Bejarano, F., Yan, Y., Grant, S., & *Li, Y. (2015). Labeling pluripotent stem cell-derived neural progenitors with iron oxide particles for magnetic resonance imaging. [Invitation to Y Li]. Methods in Molecular Biology, 1283, 43-52.

Yan, Y., Song, L., & *Li, Y. (2015). Toward Bio-manufacturing of Pluripotent Stem Cell-derived Products: Scale Out and Scale Up. [Invitation to Y Li]. Pharmaceutical Bioprocessing, 3, 25-33.

*Li, Y., Xu, C., & Ma, T. (2014). In vitro organogenesis from pluripotent stem cells (Views and Commentaries). [Invitation to Y Li]. Organogenesis, 10(2), 159-163.

Sart, S., Ma, T., & *Li, Y. (2014). Preconditioning Stem Cells for In Vivo Delivery.[Invitation to Y Li]. BioResearch Open Access, 3, 137-149.

Refereed Journal Articles

Muok, L., Liu, C., Chen, X., Arthur, P., Esmonde, C., Singh, M., Driscoll, T., & *Li, Y. (submitted). Characteristics of choroid plexus organoids derived from human pluripotent stem cells regulated by Wnt activation. Biomedicine. Manuscript submitted for publication.

Chen, X., Liu, C., Wadsworth, M., Zeng, E. Z., Driscoll, T., Zeng, C., & Li, Y. (submitted). Surface engineering of auxetic scaffolds for neural and vascular differentiation from human pluripotent stem cells. Bioactive Materials. Manuscript submitted for publication.

Jeske, R., Chen, X., Ma, S., Zeng, E., Driscoll, T. P., & *Li, Y. (submitted). Bioreactor Expansion Reconfigures Metabolism and Biogenesis of Human Adipose-derived Mesenchymal Stem Cells In Vitro. Biochemical Engineering Journal. Manuscript submitted for publication.

Helsper, S., Yuan, X., Jeske, R., Duke, L., Sun, L., Meckes, D. G., Jr., Li, Y., & Grant, S. C. (submitted). Labeling of human stem cell extracellular vesicles for in vivo MR imaging. Magnetic Resonance Medicine. Manuscript submitted for publication.

Helsper, S., Jeske, R., Liu, C., Athey, J., Meckes, D. G., Jr., Sun, L., Yuan, X., *Li, Y., & * Grant, S. C. (submitted). Mechanism of recovery following stem cell derived extracellular vesicles to cerebral ischemia. Bioactive Materials. Manuscript submitted for publication.

Russell, T., Dirir, Q., Li, Y., Chiang, C., & Yun, Y. (submitted). A microfluidic three-dimensional vascularized cortical organoid on a chip. Lab on a Chip. Manuscript submitted for publication.

Kalvala, A. K., Arthur, P., Bagde, A., Kulkarni, T., Bhattacharya, S., Surapaneni, S., Patel, N. K., Nimma, R., Gebeyehu, A., Kommineni, N., Meckes, D., Sun, L., Banzara, B., Mosley, K., Dinh, T., Li, Y., & Singh, M. (submitted). Cannabidiol Loaded Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Paclitaxel Induced Peripheral Neuropathy. Molecular Pharmaceutics. Manuscript submitted for publication.

Kalvala, A. K., Nimma, R., Bagde, A., Surapaneni, S. K., Patel, N., Arthur, P., Sun, L., Singh, R., Kommineni, N., Nathani, A., Li, Y., & Singh, M. (submitted). Transcriptomic and proteomic analysis revealed cannabidiol and tetrahydrocannabivarin signatures to overcome DOX resistance in MDA-MB-231 xenografts in athymic nude mice. Drug Delivery and Translational Research. Manuscript submitted for publication.

Arthur, P., Kandoi, S., Sun, L., Kalvala, A., Kuthleria, S., Bhattacharaya, S., Kulkarni, T., Nimma, R., *Li, Y., *Lamba, D., & *Singh, M. (in press). Biophysical, Molecular and Proteomic Profiling of Human Retinal Organoids derived Exosomes. Pharmaceutical Research.

Hua, T., Zeng, Z., Chen, J., Xue, Y., Li, Y., & Sang, Qing-Xiang. (in press). Human Malignant Rhabdoid Tumor Antigens as Biomarkers and Potential Therapeutic Targets. Cancers.

Helsper, S., Yuan, X., Bagdasarian, F. A., Athey, J., Li, Y., Borlongan, C. V., & Grant, S. C. (in press). Multinuclear MRI reveals early efficacy of stem cell therapy in stroke. Translational Stroke Research.

Hua, T., Liu, C., Kiran, S., Gray, K., Jung, J., Meckes, D. G., Jr., *Li, Y., & *Sang, Qing-Xiang. (in press). Phenotypic, Metabolic, and Biogenesis Properties of Human Stem Cell-derived Cerebellar Spheroids. Scientific Reports.

Jeske, R., Liu, C., Duke, L., Canonicco Castro, M. L., Muok, L., Arthur, P., Singh, M., Jung, S., Sun, L., & *Li, Y. (in press). Upscaling Human Mesenchymal Stem Cell Production in a Novel Vertical Wheel Bioreactor Enhances Extracellular Vesicle Secretion and Cargo Profile. Bioactive Materials.

Marzano, M., Chen, X., Russell, T. A., Medina, A., Wang, Z., Hua, T., Zeng, C., Wang, X., Sang, Q. X., Tang, H., Yun, Y., & *Li, Y. (2022). Studying the Inflammatory Responses to Amyloid Beta Oligomers in Brain-Specific Pericyte and Endothelial Co-culture from Human Stem Cells. Frontiers in Chemical Engineering, 4, 927188.

Yuan, X., Sun, L., Jeske, R., Nkosi, N., York, S., Liu, Y., Grant, S. C., Meckes, D. G., Jr., & *Li, Y. (2022). Engineering Extracellular Vesicles by Three-dimensional Dynamic Culture of Human Mesenchymal Stem Cells. Journal of Extracellular Vesicles, 11(6), e12235.

Hua, T., Kiran, S., *Li, Y., & *Sang, Qing-Xiang. (2022). Microplastics Exposure Affects Neural Development of Human Pluripotent Stem Cell-derived Cortical Spheroids. Journal of Hazardous Materials, 435, 128884.

Henderson, E., Hua, T., Kiran, S., Khamis, Z., *Li, Y., & *Sang, Qing-Xiang. (2022). Long-term Effects of nanoscale magnetite on human stem cell-derived cortical spheroids. ACS Biomaterials Science & Engineering, 8, 801-813.

Mulderrig, L., Chamber, F., Iasis, T., Jeske, R., Li, Y., Kennemur, J., & Hallinan, D. (2021). Hydrolytic Degradation of 3D-Printed Poly(lactic acid) Structures. Sustainable Development Research, 3, 17-27.

Hua, T., Bejoy, J., Song, L., Wang, Z., Zeng, Z., Zhou, Y., *Li, Y., & *Sang, Q.-X. (2021). Cerebellar Differentiation from Human Stem Cells through Retinoid, Wnt, and Sonic Hedgehog Pathways. Tissue Engineering Part A (selected as cover arts for TEA and TEC), 27, 881-893.

Marzano, M., Bou-Dargham, M., Cone, A. S., York, S., Helsper, S., Grant, S. C., Meckes, D., Jr., Sang, Q.-X., & *Li, Y. (2021). Biogenesis of Extracellular Vesicles Produced from Human Stem Cell-Derived Cortical Spheroids Exposed to Iron Oxides. ACS Biomaterials Science & Engineering, 7, 1111-1122.

Jeske, R. #., Yuan, X. #., Fu, Q., Bunnell, B. A., Logan, T. M., & *Li, Y. (2021). In Vitro Culture Expansion Shifts Immune Phenotype of Human Adipose-derived Mesenchymal Stem Cells. Frontiers in Immunology, 12, 621744.

Jeske, R. #., Lewis, S. #., Tsai, A.-C., Sanders, K., Liu, C., Yuan, X., & *Li, Y. (2021). Agitation in a Microcarrier-based Spinner Bioreactor Modulates Homeostasis of Human Mesenchymal Stem Cells. Biochemical Engineering Journal, 168, 107947.

*Yuan, X., Liu, Y., Bijonowski, B., Tsai, A.-C., Fu, Q., Logan, T. M., Ma, T., & *Li, Y. (2020). NAD+/NADH Redox Alterations Reconfigure Metabolism and Rejuvenate Senescent Human Mesenchymal Stem Cells In Vitro. Communications Biology, 3, 774-788.

Bijonowski, B. M., Yuan, X., Jeske, R., *Li, Y., & Grant, S. C. (2020). Cyclical Aggregation Extends In Vitro Expansion Potential of Human Mesenchymal Stem Cells. Scientific Reports, 10, 20448-20457.

Bijonowski, B. M., Fu, Q., Yuan, X., Irianto, J., *Li, Y., Grant, S. C., & Ma, T. (2020). Aggregation-induced Integrated Stress Response Rejuvenates Stemness of Culture-Expanded Human Mesenchymal Stem Cells. Biotechnology and Bioengineering, 117, 3136-3149.

Cone, A. S., Hurwitz, S. N., Lee, G. S., Yuan, X., Zhou, Y., Li, Y., & Meckes, D., Jr. (2020). Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. BMC Molecular and Cell Biology, 21, 58-78.

Griffin, K., Bejoy, J., Song, L., Hua, T., Marzano, M., Jeske, R., Sang, Q.-X., & *Li, Y. (2020). Human stem cell-derived aggregates of forebrain astroglia respond to amyloid beta oligomers. Tissue Engineering Part A, 26, 527-542.

Liu, L., Koo, Y., Russell, T. A., Gay, E., Li, Y., & Yun, Y. (2020). Three-dimensional brain-on-chip model using human iPSC-derived GABAergic neurons and astrocytes: Butyrylcholinesterase post-treatment for acute malathion exposure. PLOS One, 15(3), e0230335.

Bejoy, J., Bijonowski, B., Marzano, M., Jeske, R., Ma, T., & *Li, Y. (2020). Wnt-Notch signaling interactions during neural and astroglial tissue patterning of human induced pluripotent stem cells. Tissue Engineering Part A, 26, 419-431.

Marzano, M., Bejoy, J., Cheerathodi, M., Li, S., York, S., Zhao, J., Kanekiyo, T., Bu, G., *Meckes, D., & *Li, Y. (2019). Differential effects of extracellular vesicles of lineage-specific human pluripotent stem cells on cellular behaviours of isogenic cortical spheroids. Cells, 8, 993-1014.

Song, L., Yuan, X., Jones, Z., Griffin, K., Zhou, Y., *Ma, T., & *Li, Y. (2019). Assembly of human stem cell-derived cortical spheroids and vascular spheroids to model 3-D brain-like tissues. (Top 100 cell and molecular biology papers in 2019). Scientific Reports, 9, 5977-5993.

Yan, Y. #., Bejoy, J. #., Xia, J., Griffin, K., Guan, J., & *Li, Y. (2019). Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells. Scientific Reports, 9, 1295-1307.

Song, L., Yuan, X., Jones, Z., Vied, C., Miao, Y., Marzano, M., Hua, T., Sang, Qing-Xiang, Guan, J., Ma, T., Zhou, Y., & *Li, Y. (2019). Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells. Scientific Reports, 9, 11055-11072.

Bejoy, J., Yuan, X., Song, L., Hua, T., Jeske, R., Sart, S., Sang, Qing-Xiang, & *Li, Y. (2019). Genomics analysis of metabolic pathways of human stem cell-derived microglia-like cells and the integrated cortical spheroids. Stem Cells International, 2019, 2382534. doi:10.1155/2019/2382534

Bejoy, J., Wang, Z., Bijonowski, B., Yang, M., Ma, T., Sang, Q.-X., & *Li, Y. (2018). Differential effects of heparin and hyaluronic acid on neural patterning of human induced pluripotent stem cells. ACS Biomaterials Science and Engineering (selected for Supplementary Journal Cover), 4, 4354-4366.

Yan, Y., Song, L., Madinya, J., Ma, T., & *Li, Y. (2018). Derivation of cortical spheroids from human induced pluripotent stem cells in a suspension bioreactor. Tissue Engineering Part A, 24, 418-431.

Yan, Y., Song, L., Bejoy, J., Zhao, J., Kanekiyo, T., Bu, G., Zhou, Y., & *Li, Y. (2018). Modelling neurodegenerative microenvironment using cortical organoids derived from human stem cells. Tissue Engineering Part A, 24, 1125-1137.

Song, L., Tsai, Ang-chen, Yuan, X., Bejoy, J., Sart, S., *Ma, T., & *Li, Y. (2018). Neural differentiation of spheroids derived from human induced pluripotent stem cells - mesenchymal stem cells co-culture. Tissue Engineering Part A (selected as cover art), 24, 915-929.

Bejoy, J., Song, L., Wang, Z., Sang, Qing-xiang, Zhou, Y., & *Li, Y. (2018). Neuroprotective Activities of Heparin, Heparinase III, and Hyaluronic Acid on the Aβ42-treated Forebrain Spheroids Derived from Human Stem Cells. ACS Biomaterials Science and Engineering, 4, 2922-2933.

Song, L., Ahmed, F., Li, Y., Zeng, C., & *Li, Y. (2018). Vascular differentiation from pluripotent stem cells in 3-D auxetic scaffolds. Journal of Tissue Engineering and Regenerative Medicine, 12, 1679-1689.

Bejoy, J., Song, L., Zhou, Y., & *Li, Y. (2018). Wnt/Yes-associated protein interactions during neural tissue patterning of human induced pluripotent stem cells  (top cited and top trending paper of the Journal in 2020). Tissue Engineering Part A, 24, 546-558.

Liu, M., *Li, Y., & *Yang, S. T. (2017). Effects of naringin on the proliferation and osteogenic differentiation of human amniotic fluid derived stem cells. Journal of Tissue Engineering and Regenerative Medicine, 11, 276-284.

Song, L., Ahmed, F., Li, Y., Bejoy, J., Zeng, C., & *Li, Y. (2017). PCL-PDMS-PCL copolymer-based microspheres mediate cardiovascular differentiation from embryonic stem cells. Tissue Engineering Part C: Methods, 23, 627-640.

Yan, Y., Li, Y., Song, L., Zeng, C., & *Li, Y. (2017). Pluripotent stem cell expansion and neural differentiation in 3-D scaffolds of tunable Poisson's ratio. Acta Biomaterialia, 49, 192-203.

Xia, J., Wang, Z., Yan, Y., Cheng, Z., Sun, L., Li, Y., Ren, Y., & Guan, J. (2016). Catalase-laden microdevices for cell-mediated enzyme delivery. Langmuir, 32, 13386-13393.

Sart, S., Yan, Y., Li, Y., Lochner, E., Zeng, C., Ma, T., & *Li, Y. (2016). Crosslinking of extracellular matrix scaffolds derived from pluripotent stem cell aggregates modulates neural differentiation. Acta Biomaterialia, 30, 222-232.

Song, L., Wang, K., *Li, Y., & *Yang, Y. (2016). Nanotopography promoted neuronal differentiation of human induced pluripotent stem cells. Colloids and Surfaces B: Biointerfaces (selected as cover art), 148, 49-58.

Yan, Y., Bejoy, J., Xia, J., Guan, J., Zhou, Y., & *Li, Y. (2016). Neural patterning of human induced pluripotent stem cells in 3-D cultures for studying differential cellular responses. Acta Biomaterialia, 42, 114-126.

Xia, J., Wang, Z., Huang, D., Yan, Y., Li, Y., & Guan, J. (2015). Asymmetric Biodegradable Microdevices for Cell-borne Drug Delivery. ACS Applied Materials & Interfaces, 7, 6293-6299.

Yan, Y., Calixto Bejarano, F., Sart, S., Muroski, M., Strouse, G., *Grant, S., & *Li, Y. (2015). Cryopreservation of embryonic stem cell-derived multicellular neural aggregates labeled with micron-sized particles of iron oxide for magnetic resonance imaging. Biotechnology Progress, 31, 510-521.

Yan, Y., Martin, L., Bosco, D., Bundy, J., Nowakowski, R., Sang, Q.-X. Amy, & *Li, Y. (2015). Differential effects of acellular embryonic matrices on pluripotent stem cell expansion and neural differentiation. Biomaterials, 73, 231-242.

Wang, Z., Xia, J., Yan, Y., Tsai, A.-C., Li, Y., Ma, T., & Guan, J. (2015). Facile functionalization and assembly of live cells with microcontact printed polymeric biomaterials. Acta Biomaterialia, 11, 80-87.

Sart, S., Calixto Bejarano, F., Baird, M., Yan, Y., Rosenberg, J., Ma, T., *Grant, S., & *Li, Y. (2015). Intracellular labeling of pluripotent stem cell-derived neural progenitor aggregates with micron-sized particles of iron oxide. Cytotherapy, 17, 98-111.

Sart, S., Yan, Y., & *Li, Y. (2015). The microenvironment of embryoid bodies modulated the commitment to neural lineage post-cryopreservation. Tissue Engineering Part C: Methods, 21, 356-366.

Liu, M., Li, Y., & Yang, S. T. (2014). Curculigoside improves osteogenesis of human amniotic fluid derived stem cells. Stem Cells and Development, 23, 146-154.

Liu, N., Li, Y., & Yang, S.-T. (2014). Expansion of embryonic stem cells in suspension and fibrous bed bioreactors. Journal of Biotechnology, 178, 54-64.

Liu, M., Li, Y., & Yang, S.-T. (2014). Expansion of human amniotic fluid stem cells in 3-Dimensional fibrous scaffolds in stirred bioreactors. Biochemical Engineering Journal, 82, 71-80.

Sart, S., *Ma, T., & *Li, Y. (2014). Extracellular matrices decellularized from embryonic stem cells maintained their structure and signaling specificity. Tissue Engineering Part A, 20, 54-66.

Sart, S., Liu, Y., *Ma, T., & *Li, Y. (2014). Microenvironment regulation of pluripotent stem cell-derived neural progenitor aggregates by human mesenchymal stem cell secretome. Tissue Engineering Part A, 20, 2666-2679.

Sart, S., Ma, T., & *Li, Y. (2013). Cryopreservation of pluripotent stem cell aggregates in defined protein-free formulation. Biotechnology Progress, 29, 143-153.

Liu, N., Li, Y., & Yang, S. T. (2013). Microfibrous carriers for integrated expansion and neural differentiation of embryonic stem cells in suspension bioreactor. Biochemical Engineering Journal, 75, 55-63.

*Li, Y., Gautam, A., Yang, J., Qiu, L., Melkoumian, Z., Weber, J., Telukuntla, L., Srivastava, R., Whiteley, E., & Brandenberger, R. (2013). Oligodendrocyte progenitor cell differentiation from human embryonic stem cells on vitronectin-derived synthetic peptide acrylate surface. Stem Cells and Development, 22, 1497-1505.

Liu, N., Ouyang, A., Li, Y., & Yang, S. T. (2013). Three-dimensional neural differentiation of embryonic stem cells with ACM induction in microfibrous matrices in bioreactors. Biotechnology Progress, 29, 1013-1022.

Xu, C., Police, S., Hassanipour, M., Li, Y., Chen, Y., Priest, C., O'Sullivan, C., Laflamme, M. A., Zhu, Wei-Zhong, Biber, B. V., Hegerova, L., Yang, J., Delavan-Boorsma, K., Davies, A., Lebkowski, J., & Gold, J. D. (2011). Efficient generation and cryopreservation of cardiomyocytes derived from human embryonic stem cells. Regenerative Medicine, 6, 53-66.

Li, Y., Powell, S., Brunette, E., Lebkowski, J., & Mandalam, R. (2005). Expansion of human embryonic stem cells in defined serum-free medium devoid of animal-derived products. Biotechnology and Bioengineering, 91, 688-698.

Genbacev, O., Krtolica, A., Zdravkovic, T., Brunette, E., Powell, S., Nath, A., Caceres, E., McMaster, M., McDonagh, S., Li, Y., Mandalam, R., Lebkowski, J., & Fisher, S. J. (2005). Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders. Fertility and Sterility, 83, 1517-1529.

Brandenberger, R., Wei, H., Zhang, S., Lei, S., Murage, J., Fisk, G., Li, Y., Xu, C., Fang, R., Guegler, K., Rao, M. S., Mandalam, R., Lebkowski, J., & Stanton, L. W. (2004). Signaling networks that control human ES cell growth and differentiation elucidated by transcriptome characterization. Nature Biotechnology, 22, 707-716.

Li, Y., Kniss, D. A., Lasky, L. C., & Yang, S. T. (2003). Culturing and differentiation of murine embryonic stem cells in 3-D fibrous matrix. Cytotechnology, 41, 23-35.

Kniss, D. A., Xie, Y., Li, Y., Kumar, S., Linton, E. A., Cohen, P., Fan-Havard, P., Redman, C. W., & Sargent, I. L. (2002). ED27 trophoblast-like cells isolated from first-trimester chorionic villi are genetically identical to HeLa cells yet exhibit a distinct phenotype. Placenta, 23, 32-43.

Xie, Y., Sproule, T., Li, Y., Powell, H., Lannutti, J., & Kniss, D. A. (2002). Nanoscale modifications of PET polymer surfaces via oxygen-plasma discharge yield minimal changes in attachment and growth of mammalian epithelial and mesenchymal cells in vitro. Journal of Biomedical Materials Research, 61, 234-245.

Li, Y., Ma, T., Kniss, D. A., Lasky, L. C., & Yang, S. T. (2001). Effects of filtration seeding on cell density, spatial distribution and proliferation in nonwoven fibrous matrices. Biotechnology Progress, 17, 935-944.

Li, Y., Ma, T., Kniss, D. A., Yang, S. T., & Lasky, L. C. (2001). Human cord cell hematopoiesis and expansion in 3-D nonwoven fibrous matrices: In vitro simulation of the marrow microenvironment. Journal of Hematotherapy & Stem Cell Research, 10, 355-368.

Li, Y., Ma, T., Yang, S. T., & Kniss, D. A. (2001). Thermal compression and characterization of 3-D nonwoven PET matrices as tissue engineering scaffolds. Biomaterials, 22, 609-618.

Ma, T., Li, Y., Yang, S. T., & Kniss, D. A. (2000). Effects of pore size in 3-D fibrous matrix on human trophoblast tissue development. Biotechnology and Bioengineering, 70, 606-618.

Ma, T., Li, Y., Yang, S. T., & Kniss, D. A. (1999). Tissue engineering human placenta trophoblast cells in 3-D fibrous matrix: spatial effects on cell proliferation and function. Biotechnology Progress, 15, 715-724.

Refereed Book Chapters

Liu, Y., Tsai, A.-C., Yuan, X., Li, Y., & Ma, T. (2017). Hypoxia Regulation of Stem Cell: Mechanisms, Biological Properties, and Applications. In In Ajaykumar Vishwakarma and Jeffrey Karp (ed.). (Ed.), Biology and Engineering of Stem Cell Niches (pp. 273-291). Elsevier. Amsterdam, Netherlands. Retrieved from DOI: 10.1016/B978-0-12-802734-9.00018-4.

Mandalam, R., Li, Y., Powell, S., Brunette, E., & Lebkowski, J. (2005). Chapter 15: Production of human embryonic stem cell derived cellular product for therapeutic use. In J. Odorico, S-C. Zhang, & R. Pedersen (Eds.), Human embryonic stem cells (pp. 289-299). Oxon, UK and New York, USA: BIOS Scientific Publishers. 

Li, Y., & Yang, S. T. (2004). Stem cell-based tissue engineering. In D. R. Heldman (Ed.), Encyclopedia of Agricultural, Food, and Biological Engineering (pp. 1-6). Marcel Dekker. 

Refereed Reviews

Al-Akkary, N., Khamis, Z. I., Hua, T., Draughon, S., Li, Y., & Sang, Qing-Xiang Amy. (2021). Clinical Investigations of Immunotherapy for Human Primary Brain Tumors. Neuroimmunology and Neuroinflammation, 8, 157-173.

Sart, S., Jeske, R., Chen, X., Ma, T., & *Li, Y. (2020). Engineering stem cell-derived extracellular matrices: decellularization, characterization, and biological function. Tissue Engineering Part B: Reviews, 26, 402-422.

Jeske, R. #., Albo, J. #., Marzano, M. #., Bejoy, J., & *Li, Y. (2020). Engineering Brain-Specific Pericytes from Human Pluripotent Stem Cells. Tissue Engineering Part B: Reviews, 26, 367-382.

Jeske, R. #., Bejoy, J. #., Marzano, M. #., & *Li, Y. (2020). Human Pluripotent Stem Cell-derived Extracellular Vesicles: Characteristics and Applications. Tissue Engineering Part B: Reviews, 26, 129-144.

Sart, S., Agathos, S., Li, Y., & Ma, T. (2016). Regulation of mesenchymal stem cell 3D microenvironment: from macro to microfluidic bioreactors. Biotechnology Journal, 11, 43-57.

Li, Y., Liu, M., & Yang, S. T. (2014). Dendritic cells derived from pluripotent stem cells: potential of large scale production (Headline Article). World Journal of Stem Cells, 6, 1-10.

Li, Y., Liu, M., Yan, Y., & Yang, S. T. (2014). Neural differentiation from pluripotent stem cells: the role of natural and synthetic extracellular matrix (Headline Article). World Journal of Stem Cells, 6, 11-23.

Sart, S., *Agathos, S. N., & *Li, Y. (2014). Process engineering of stem cell metabolism for large scale expansion and differentiation in bioreactors. Biochemical Engineering Journal, 84, 74-82.

Sart, S., Schneider, Y., *Li, Y., & Agathos, S. N. (2014). Stem cell bioprocess engineering towards cGMP production and clinical applications. Cytotechnology, 66, 709-722.

Liu, N., Zang, R., *Yang, S. T., & *Li, Y. (2014). Stem cell engineering in bioreactors for large scale bioprocessing (Selected in "In This Issue" highlight). Engineering in Life Sciences, 14, 4-15.

Sart, S., Tsai, A.-C., Li, Y., & Ma, T. (2014). Three-dimensional aggregates of mesenchymal stem cells: cellular mechanisms, biological properties, and applications. Tissue Engineering Part B Reviews, 20, 365-380.

Mooney, B. M., Raof, N. A., Li, Y., & Xie, Y. (2013). Convergent mechanisms in pluripotent stem cells and cancer: Implications for stem cell engineering. Biotechnology Journal, 8, 408-419.

Sart, S., *Agathos, S. N., & *Li, Y. (2013). Engineering stem cell fate with biochemical and biomechanical properties of microcarriers. Biotechnology Progress, 29, 1354-1366.

Liu, M., Liu, N., Zang, R., Li, Y., & Yang, S. T. (2013). Engineering stem cell niches in bioreactors. (High impact papers, #16 of 20, May 2014). World Journal of Stem Cells, 5, 124-135.

*Li, Y., & Ma, T. (2012). Bioprocessing of cryopreservation for large scale banking of human pluripotent stem cells. BioResearch Open Access, 1, 205-214.

Li, Y., & Ma, T. (2011). Stem cell-based dendritic cell vaccine development: a review with emphasis on lung cancer treatment. Journal of Hematological Malignancies, 1, 35-48.

Li, Y., & Yang, S. T. (2001). Review: Effects of three-dimensional scaffolds on cell organization and tissue development. Biotechnology and Bioprocess Engineering, 6, 311-325.

Nonrefereed Summaries

Li, Y., & Yang, S. T. (2014). Summary of Advances in human pluripotent stem cells for regenerative medicine and drug discovery (editorial). Journal of Tissue Science and Engineering, 5, e127.

Yan, Y., Sart, S., & Li, Y. (2013). Summary of Differentiation of neural progenitor cells from pluripotent stem cells in artificial niches. International Journal of Stem Cell Research and Transplantation, 1, 401-409.

Li, Y., Sart, S., & Agathos, S. N. (2013). Summary of Mass production of stem cell-derived progeny in bioreactors (Editorial). International Journal of Stem Cell Research and Transplantation, 1, 201-203.

Li, Y., & Yang, S. T. (2013). Summary of Metabolic regulation of pluripotent stem cell expansion, differentiation, and reprogramming (editorial). Journal of Tissue Science and Engineering, 4, e125.

Presentations

Invited Presentations at Conferences

Sart, S (Presenter), Agothas, S. N., & Li, Y. (presented 2014, November). Process engineering of stem cell metabolism for large-scale expansion and differentiation in bioreactors. Presentation at the meeting of Industrial Forum: Advances in Biotechnology. 2014 Annual Meeting of American Institute of Chemical Engineers (AIChE), Atlanta, GA. (National)

Li, Y. (presented 2014, March). Neural differentiation and imaging of pluripotent stem cells: the applications of biomaterials. Presentation at Advancing the Science and Technology of Materials, Interfaces, and Processing, 2014 Florida AVS/FSM joint Symposium, Orlando, FL. (Regional)

Sart, S (Presenter), Agathos, S. N., & Li, Y. (presented 2013, November). Stem Cell Expansion and Differentiation in Microcarrier-based Bioreactors for Large Scale Production. Presentation at Industrial Forum: Advances in Biotechnology, Annual Meeting of American Institute of Chemical Engineers (AIChE), San Francisco, CA. (National)

Li, Y. (presented 2013, August). Neural differentiation of pluripotent stem cells and the intracellular labeling with superparamagnetic iron oxide nanoparticles. Presentation at The Third EITA Young Investigator Conference, EITA, Massachusetts Institute of Technology (MIT), Cambridge, MA. (National)

Refereed Presentations at Conferences

Muok, L., Liu, C., Chen, X., Driscoll, T. P., & Li, Y. (accepted). Engineering choroid plexus organoids derived from human pluripotent stem cells. Presentation to be given at BMES 2022 annual meeting, BMES, San Antonio, TX. (National)

Liu, C., Chen, X., Sun, L., Zeng, C., & Li, Y. (accepted). Engineering extracellular matrix-bound nanovesicles secreted by human stem cells. Presentation to be given at BMES 2022 annual meeting, BMES, San Antonio, TX. (National)

Jeske, R., Chen, X., Mulderrig, L., Cheng, W., Zeng, C., Guan, J., Hallinan, D., & Li, Y. (accepted). Engineering human mesenchymal bodies for exosome secretion in a novel 3-D printed microchannel bioreactor. Presentation to be given at AIChE 2022 annual meeting, AIChE. (National)

Liu, C., Marzamo, M., Helsper, S., Chen, X., Muok, L., Zeng, C., Sun, L., Grant, S. C., & Li, Y. (accepted). Human forebrain organoid-derived extracellular vesicle labelling with iron oxides for magnetic resonance imaging. Presentation to be given at AIChE 2022 annual meeting, AIChE. (National)

Chen, X., Liu, C., Driscoll, T., Zeng, C., & Li, Y. (accepted). Surface engineering of auxetic scaffolds for neural and vascular differentiation from human stem cells. Presentation to be given at AIChE 2022 annual meeting, AIChE, Phonex, AZ. (National)

Jeske, R., Sun, L., Liu, C., Duke, L., Jung, S., Meckes, D. G., Jr., & Li, Y. (presented 2022, June). Engineering Extracellular Vesicles of Human Mesenchymal Stem Cells through Metabolic Alterations in a Novel Vertical Wheel Bioreactor. Presentation at ISSCR 2022 annual meeting, International Society for Stem Cell Research (ISSCR), San Francisco, CA. (International)

Hua, T., Kiran, S., *Li, Y., & *Sang, Qing-Xiang. (presented 2022, June). Microplastics Exposure Affects Neural Development of Human Pluripotent Stem Cell-derived Cortical Spheroids. Presentation at ISSCR 2022 annual meeting, International Society for Stem Cell Research (ISSCR), San Francisco, CA. (International)

Helsper, S., Yuan, X., Jeske, R., Sun, L., Meckes, D. G., Jr., Li, Y., & Grant, S. C. (presented 2022, May). Mechanism of recovery following stem cell therapy in ischemic stroke: cell or secretome? Presentation at Annual Meeting of International Society for Magnetic Resonance in Medicine, ISMRM, London, UK. (International)

Canónicco Castro, M. L., Jeske, R., & Li, Y. (presented 2021, November). Analysis of Shear Stress Profiles in a Novel Vertical Wheel Bioreactor for Human Stem Cell-Based Therapy. Presentation at 2021 Annual Meeting of AIChE, AIChE. (National)

Henderson, E., Kiran, S., Hua, T., Khamis, Z., Li, Y., & Sang, Qing-Xiang. (presented 2021, November). Effects of Nanoscale Magnetite on Human Forebrain-like Tissue Development in Stem Cell-Derived Cortical Spheroids. Presentation at 2021 Annual Meeting of AIChE, AIChE, Boston, MA. (National)

Chen, X., Liu, C., Wang, X., Zeng, C., & Li, Y. (presented 2021, November). Engineering auxetic scaffolds for human stem cell differentiation. Presentation at 2021 Annual Meeting of AIChE, AIChE, Boston, MA. (National)

Jeske, R., Xuegang Yuan, Jung, S., Meckes, D., & Li, Y. (presented 2021, November). Shear Stress Effects on Energy Metabolism and Exosome Secretion of Human Mesenchymal Stem Cells in a Novel PBS Vertical Wheel Bioreactor. Presentation at 2021 Annual Meeting of AIChE, AIChE, Boston, MA. (National)

Jeske, R., Liu, C., Chen, X., Muok, L., Yuan, X., & Li, Y. (presented 2021, November). Shear Stress in a Spinner Flask Bioreactor Alters Energy Metabolism and Replicative Senescence of Human Mesenchymal Stem Cells. Presentation at 2021 Annual Meeting of AIChE, AIChE, Boston, MA. (National)

Kiran, S., Hua, T., Li, Y., & Sang, Q.-X. (presented 2021, November). Size-Dependent Polystyrene Microplastic Exposure to the Developing Human Induced Pluripotent Stem Cell Derived Cortical Spheroids: Effects and Implications. Presentation at 2021 Annual Meeting of AIChE, AIChE, Boston, MA. (National)

Hua, T., Liu, C., Kiran, S., Li, Y., & Sang, Qing-Xiang. (presented 2021, October). Early Cerebellar Markers of Human Stem Cells Are Promoted by Retinoid, Wnt, and Sonic Hedgehog Pathways. Presentation at 2021 Annual Meeting of BMES, Biomedical Engineering Society, Orlando, FL. (National)

Marzano, M., Chen, X., Hua, T., Zeng, C., Sang, Qing-Xiang, & Li, Y. (presented 2021, October). Engineering Brain-Specific Pericyte and Endothelial Cell Co-culture from Human Stem Cells for Studying Immune Response. Presentation at 2021 Annual Meeting of BMES, Biomedical Engineering Society, Orlando, FL. (National)

Arthur, P., Kutlehria, S., Muok, L., *Li, Y., & Sachdeva, M. (presented 2021, October). Retinal Photoreceptor Differentiation from Human Pluripotent Stem Cells for Exosome-based Drug Delivery. Presentation at 2021 Annual Meeting of BMES, Biomedical Engineering Society, Orlando, FL. (National)

Jeske, R., Yuan, X., Bunnell, B. A., & Li, Y. (presented 2021, July). In Vitro Culture Expansion Shifts the Immune Phenotype of Human Adipose-derived Mesenchymal Stem Cells. Presentation at 8th International Conference on Stem Cell Engineering, Society for Biological Engineering, Boston, MA (Virtual). (International)

Jeske, R., Lewis, S., Tsai, A.-C., Sanders, K., Yuan, X., & *Li, Y. (presented 2020, November). Agitation in a Microcarrier-based Spinner Bioreactor Modulates Homeostasis of Human Mesenchymal Stem Cells. Presentation at 2020 Annual Meeting of AIChE, AIChE, Virtual. (National)

Bijonowski, B. M., Jeske, R., *Li, Y., & Grant, S. C. (presented 2020, November). Cyclical aggregation extends in vitro expansion potential of human mesenchymal stem cells. Presentation at 2020 Annual Meeting of AIChE, AIChE, Virtual. (National)

Jeske, R. #., Yuan, X. #., Qin, F., & *Li, Y. (presented 2020, November). Metabolic Characteristics and Immunomodulation of Human Adipose-derived Stem Cells during In Vitro Culture Expansion. Presentation at 2020 Annual Meeting of AIChE, AIChE, Virtual. (National)

Kutlehria, S., Marzano, S., Arthur, P., *Li, Y., & Sachdeva, M. (presented 2020, November). Retinal photoreceptor differentiation from human pluripotent stem cells for 3-D bio-printing. Presentation at 2020 Annual Meeting of AIChE, AIChE, Virtual. (National)

Yuan, X., Nkosi, D., Liu, Y., York S., Sun, L., Ma, T., Li, Y., Grant, S., & Meckes, D. (presented 2020, November). Scale-up of Extracellular Vesicles Production with Modified Cargo Profile from Human Mesenchymal Stem Cells Via Three-Dimensional Dynamic Culture. Presentation at 2020 Annual Meeting of AIChE, AIChE, Virtual. (National)

Hua, T., Zhou, Y., *Li, Y., & Sang, Q.-X. (presented 2020, October). Cerebellar Organoid Differentiation from Human Induced Pluripotent Stem Cells Using Caudalization Factors. Presentation at 2020 Biomedical Engineering Society (BMES) Annual Meeting, BMES, Virtual. (National)

Yuan, X., Jeske, R., Qin, F., & *Li, Y. (presented 2020, October). Metabolic Characteristics and Immunomodulation of Human Adipose-derived Stem Cells during In Vitro Culture Expansion. Presentation at 2020 Biomedical Engineering Society (BMES) Annual Meeting, BMES, Virtual. (National)

Marzano, M., Bou-Dargham, M., Cone, A., York, S., Helsper, S., Grant, S. C., Meckes, D., Jr., Sang, Q.-X., & Li, Y. (presented 2020, October). Nanoscale iron oxide-labelled human stem cell-derived cortical spheroids retain biogenesis of extracellular vesicles. Presentation at 2020 Biomedical Engineering Society (BMES) Annual Meeting, BMES, Virtual. (National)

Yuan, X., Nkosi, D., Liu, Y., York, S., Sun, L., Ma, T., Li, Y., Grant, S., & Meckes, D. (presented 2020, October). Three-dimensional Dynamic Culture Improves Extracellular Vesicle Production and Cargo Profile of Human Mesenchymal Stem Cells through Altered Biogenesis. Presentation at 2020 Biomedical Engineering Society (BMES) Annual Meeting, BMES, Virtual. (National)

Hua, T., Bejoy, J., Song, L., Wang, Z., Li, Y., & Sang, Q.-X. (presented 2019, November). Deriving cerebellum-like organoids from induced pluripotent stem cells. Presentation at 2019 Annual Meeting of American Institute of Chemical Engineers (AIChE), November 10-15, Orlando, FL, 2019, AIChE. (National)

Marzano, M., Bejoy, J., Meckes, D., & Li, Y. (presented 2019, November). Differential effects of extracellular vesicles of lineage-specific human pluripotent stem cells on cellular behaviours of isogenic cortical spheroids. Presentation at 2019 Annual Meeting of American Institute of Chemical Engineers (AIChE), November 10-15, Orlando, FL, 2019, AIChE. (National)

Bejoy, J., Wang, Z., Bijonowski, B., Yang, M., Ma, T., Sang, Q.-X., & Li, Y. (presented 2019, November). Differential effects of heparin and hyaluronic acid on neural patterning of human induced pluripotent stem cells. Presentation at 2019 Annual Meeting of American Institute of Chemical Engineers (AIChE), November 10-15, Orlando, FL, 2019, AIChE. (National)

Griffin, K., Bejoy, J., Song, L., & Li, Y. (presented 2019, November). Engineering and Characterization of Human Stem Cell-derived Multicellular Aggregates of Glial Cells. Presentation at 2019 Annual Meeting of American Institute of Chemical Engineers (AIChE), November 10-15, Orlando, FL, 2019, AIChE. (National)

Song, L., Yuan, X., Jones, Z., Vied, C., Miao, Y., Marzano, M., Guan, J., Ma, T., Zhou, Y., & Li, Y. (presented 2019, November). Engineering brain region-specific organoids containing isogenic microglia-like cells for immune function. Presentation at 2019 Annual Meeting of American Institute of Chemical Engineers (AIChE), November 10-15, Orlando, FL, 2019, AIChE. (National)

Bejoy, J., Song, L., Marzano, M., & Li, Y. (presented 2019, November). Genomics analysis of metabolic pathways of human stem cell-derived microglia-like cells and the integrated cortical spheroids. Presentation at 2019 Annual Meeting of American Institute of Chemical Engineers (AIChE), November 10-15, Orlando, FL, 2019, AIChE. (National)

Bejoy, J., Bijonowski, B., Ma, T., & Li, Y. (presented 2019, November). Wnt-Notch signaling interactions during neural and glial patterning of human induced pluripotent stem cells. Presentation at 2019 Annual Meeting of American Institute of Chemical Engineers (AIChE), November 10-15, Orlando, FL, 2019, AIChE. (National)

Song, L., Yuan, X., Griffin, K., Ma, T., & Li, Y. (presented 2018, October). Assembly of human stem cell-derived vascular and cortical spheroids to model 3-D brain-like tissues. Presentation at 2018 Biomedical Engineering Society (BMES) Annual Meeting, Oct 17-20, Atlanta, GA, 2018, BMES. (National)

Song, L., Yuan, X., Ma, T., & Li, Y. (presented 2018, October). Assembly of human stem cell-derived vascular spheroids and cortical spheroids to model 3-D brain-like tissues. Presentation at 2018 Annual Meeting of American Institute of Chemical Engineers (AIChE), Oct 28-Nov 02, Pittsburgh, PA 2018, AICHE. (National)

Bejoy, J., Yan, Y., Xia, J., Griffin, K., Guan, J., & Li, Y. (presented 2018, October). Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells. Presentation at 2018 Annual Meeting of American Institute of Chemical Engineers (AIChE), Oct 28-Nov 02, Pittsburgh, PA 2018, AIChE. (National)

Bejoy, J., Yan, Y., Xia, J., Griffin, K., Guan, J., & LI, Y. (presented 2018, October). Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells. Presentation at 2018 Biomedical Engineering Society (BMES) Annual Meeting, Oct 17-20, Atlanta, GA, 2018, BMES. (National)

Song, L., Yuan, X., Jones, Z., Miao, Y., Guan, J., Ma, T., Zhou, Y., & Li, Y. (presented 2018, October). Functionalization of brain region-specific organoids with isogenic microglia-like cells. Presentation at 2018 Biomedical Engineering Society (BMES) Annual Meeting, Oct 17-20, Atlanta, GA, 2018, BMES. (National)

Bejoy, J., Song, L., Wang, Z., Sang, Q.-X., Zhou, Y., & Li, Y. (presented 2018, October). Neuroprotective Activities of Heparin, Heparinase III, and Hyaluronic Acid on the Aβ42-treated Forebrain Spheroids Derived from Human Stem Cells. Presentation at 2018 Biomedical Engineering Society (BMES) Annual Meeting, Oct 17-20, Atlanta, GA, 2018, BMES. (National)

Song, L., Tsai, A-C., Yuan, X., Bejoy, J., Sart, S., Ma, T., & Li, Y. (presented 2018, May). Heterotypic cell-cell interaction of human stem cells for neural differentiation of hybrid spheroids (supported by Graduate Student Travel Grant $2030 from the meeting). Presentation at Cell Culture Engineering XVI, Engineering Conference International (ECI), May 6-11, 2018, Tampa, FL. (International)

Li, Y. (presented 2017, December). Engineering human stem cell-derived brain organoids. Presentation at Mayo Clinic and Florida State University Collaboration for Accelerated Innovation Workshop, Mayo-FSU. (Regional)

Song, L., Tsai, A.-C., Yuan, X., Bejoy, J., Sart, S., Ma, T., & Li, Y. (presented 2017, October). Heterotypic cell-cell interactions of human induced pluripotent stem cells and human mesenchymal stem cells for neural differentiation. Presentation at 2017 Annual Meeting of AIChE, American Institute of Chemical Engineers (AIChE), Oct 29-Nov 03, Minneapolis, MN 2017. (National)

Yan, Y., Song, L., Bejoy, J., Zhou, Y., & Li, Y. (presented 2017, October). Modelling Alzheimer's disease using cortical organoids derived from human induced pluripotent stem cells. Presentation at 2017 Annual Meeting of AIChE, American Institute of Chemical Engineers (AIChE), Oct 29-Nov 03, Minneapolis, MN 2017. (National)

Xia, J., Wang, Z., Yan, Y., Cheng, Z., Sun, L., Li, Y., Ren, Y., & Guan, J. (presented 2016, November). Catalase-Laden Microdevices for Cell-Mediated Enzyme Delivery. Presentation at 2016 Annual Meeting of AIChE, Nov 13-18, San Francisco, CA, 2016, AIChE. (International)

Yan, Y., Song, L., Madinya, J., & Li, Y. (presented 2016, November). Engineering cortical organoids derived from human induced pluripotent stem cells in a suspension bioreactor. Presentation at 2016 Annual Meeting of AIChE, Nov 13-18, San Francisco, CA, 2016, AIChE. (International)

Song, L., Wang, K., Yang, Y., & Li, Y. (presented 2016, November). Nanotopography promotes neuronal differentiation of human induced pluripotent stem cells. Presentation at 2016 Annual Meeting of AIChE, Nov 13-18, San Francisco, CA, 2016, AIChE. (International)

Bejoy, J., Song, L., & Li, Y. (presented 2016, November). Wnt-YAP interactions during neural tissue patterning of human induced pluripotent stem cells. Presentation at 2016 Annual Meeting of AIChE, Nov 13-18, San Francisco, CA, 2016, AIChE. (International)

Yan, Y., Song, L., & Li, Y. (presented 2016, October). Derivation of cortical spheroids from human induced pluripotent stem cells in a suspension bioreactor. Presentation at 2016 Biomedical Engineering Society (BMES) Annual Meeting, Oct 5-8, Minneapolis, Minnesota, 2016, BMES. (National)

Wang, K., Song, L., Li, Y., & Yang, Y. (presented 2016, October). Nanotopography promoted neuronal differentiation of human induced pluripotent stem cells. Presentation at 2016 Biomedical Engineering Society (BMES) Annual Meeting, Oct 5-8, Minneapolis, Minnesota, 2016, BMES. (International)

Bejoy, J., Song, L., & Li, Y. (presented 2016, October). Wnt-YAP interactions during neural tissue patterning of human induced pluripotent stem cells. Presentation at 2016 Biomedical Engineering Society (BMES) Annual Meeting, Oct 5-8, Minneapolis, Minnesota, 2016, BMES. (National)

Bejoy, J., Song, L., & Li, Y. (presented 2016, May). Biological relevance of YAP regulation by Wnt signaling during neural tissue patterning of human induced pluripotent stem cells. Presentation at the meeting of ECI Cell Culture Engineering Conference XV, May 8-13, 2016, La Quinta, CA. (International)

Yan, Y., Bejoy, J., Xia, J., Guan, J., Zhou, Y., & Li, Y. (presented 2016, May). Neural patterning of human induced pluripotent stem cells for studying neurotoxicity. (supported by Graduate Student Travel Grant $2495 from the meeting). Presentation at the meeting of ECI Cell Culture Engineering Conference XV, May 8-13, 2016, La Quinta, CA. (International)

Song, L., Li, Y., Bejoy, J., Ahmed, F., Zeng, C., & Li, Y. (presented 2016, May). PCL-PDMS-PCL microspheres modulate cardiovascular differentiation from embryonic stem cells. Presentation at the meeting of ECI Cell Culture Engineering Conference XV, May 8-13, 2016, La Quinta, CA. (International)

Yan, Y., Song, L., & Li, Y. (presented 2016, March). Derivation of cortical spheroids from human induced pluripotent stem cells in a suspension bioreactor. Presentation at 20th Annual Hilton Head Workshop, March 16-19, Hilton Head Island, SC, 2016, Regenerative Medicine: Discovery, Technology & Translation. (National)

Yan, Y., Bejoy, J., Xia, J., Guan, J., Zhou, Y., & Li, Yan (presenter). (presented 2016, March). Neural patterning of human induced pluripotent stem cells for studying differential cellular responses. Presentation at 20th Annual Hilton Head Workshop. March 16-19, Hilton Head Island, SC, 2016, Regenerative Medicine, Discovery, Technology & Translation. (National)

Yan, Y., Martin, L., Bosco, D., Bundy, J., Nowakowski, R., Sang, Q.-X. Amy, & Li, Y. (presented 2015, November). Differential effects of acellular embryonic matrices on pluripotent stem cell expansion and neural differentiation. Presentation at 2015 Annual Meeting of AIChE, Nov 8-13, Salt Lake City, UT, AIChE. (International)

Song, L., Li, Y., Bejoy, J., Ahmed, F., Zeng, C., & Li, Y. (presented 2015, November). PCL-PDMS-PCL copolymer-based microspheres mediated cardiovascular differentiation from embryonic stem cells. Presentation at 2015 Annual Meeting of AIChE, Nov 8-13, Salt Lake City, UT, AIChE. (International)

Yan, Y., Bejoy, J., Zhou, Y., & Li, Y. (presented 2015, November). Three-dimensional neural microtissue models derived from human induced pluripotent stem cells. Presentation at 2015 Annual Meeting of AIChE, Nov 8-13, Salt Lake City, UT, AIChE. (International)

Song, L., Li, Y., Zeng, C., & Li, Y. (presented 2015, November). Vascular differentiation from embryonic stem cells in 3-D auxetic scaffolds. Presentation at 2015 Annual Meeting of AIChE, Nov 8-13, Salt Lake City, UT, AIChE. Nominated for BEJ Poster Award. (International)

Xia, J., Wang, Z., Huang, D., Yan, Y., Li, Y., & Guan, J. (presented 2015, October). Asymmetric Biodegradable Microdevices for Cell-borne Drug Delivery. Presentation at 2015 BMES Annual Meeting, Oct 7-10, 2015, Tampa, Florida, Biomedical Engineering Society. (National)

Yan, Y., Bejoy, J., Zhou, Y., & Li, Y. (presented 2015, October). Three-dimensional neural differentiation from human induced pluripotent stem cells. Presentation at 2015 BMES Annual Meeting, Oct 7-10, 2015, Tampa, Florida, Biomedical Engineering Society. (National)

Yan, Y., & Li, Y. (presented 2015, May). Acellular Matrix-mediated Pluripotent Stem Cell Expansion and Neural Differentiation. Presentation at the meeting of Regenerative Medicine: Discovery, Technologies & Translation. 19th Annual Hilton Head Workshop, May 13-16, Hilton Head Island, SC, 2015. (National)

Sart, S., Yan, Y., Lochner, E., Ma, T., & Li, Y. (presented 2015, May). Extracellular Matrix Scaffolds Derived from Pluripotent Stem Cell Aggregates Regulate Stem Cell Proliferation and Differentiation. Presentation at the meeting of 24th European Society for Animal Cell Technology (ESACT) meeting, May 31-June 3, Barcelona, Spain 2015. (International)

Yan, Y., Martin, L., Bosco, D., Nowakowski, R., Sang, Qing-Xiang Amy, & Li, Y. (presented 2015, January). Acellular Matrices Derived from Pluripotent Stem Cells Modulated Tissue Development. Presentation at Scale-Up and Manufacturing of Cell-Based Therapies IV. Jan 18-22, San Diego, CA, 2015, Engineering Conferences International (ECI). (International)

Li, Y. (presented 2014, November). Active Learning in Small Classroom and Large Classroom of Fundamental Chemical Engineering Courses. Presentation at 2014 Annual Meeting of AIChE, Nov 16-21, Atlanta, GA, AIChE. (National)

Sart, S., Calixto Bejarano, F., Baird, M. A., Yan, Y., Rosenberg, J. T., Ma, T., Grant, S., & Li, Y. (presented 2014, November). Biological effects of Micron-sized Particles of Iron Oxide on Pluripotent Stem Cell-derived Neural Progenitor Aggregates for Magnetic Resonance Imaging. Presentation at 2014 Annual Meeting of AIChE, Nov 16-21, Atlanta, GA, AIChE. (National)

Sart, S., Yan, Y., Lochner, E., Ma, T., & Li, Y. (presented 2014, November). Crosslinking of Extracellular Matrix Scaffolds Derived from Pluripotent Stem Cell Aggregates for Neural Differentiation. Presentation at 2014 Annual Meeting of AIChE, Nov 16-21, Atlanta, GA, AIChE. (National)

Yan, Y., Calixto Bejarano, F., Sart, S., Muroski, M., Strouse, G., Grant, S., & Li, Y. (presented 2014, November). Cryopreservation of Pluripotent Stem Cell-derived Neural Progenitor Aggregates Labeled with Iron Oxide Particles for MRI Analysis. Presentation at 2014 Annual Meeting of AIChE, Nov 16-21, Atlanta, GA, AIChE. (National)

Wang, Z., Xia, J., Yan, Y., Tsai, A.-C., Li, Y., Ma, T., & Guan, J. (presented 2014, November). Facile Functionalization and Assembly of Live Cells with Microcontact Printed Polymeric Biomaterials. Presentation at 2014 Annual Meeting of AIChE, Nov 16-21, Atlanta, GA, AIChE. (National)

Yan, Y., Li, Y., Song, L., Zeng, C., & Li, Y. (presented 2014, November). Pluripotent Stem Cell Expansion and Neural Differentiation in 3-D Scaffolds after Auxetic Conversion. Presentation at 2014 Annual Meeting of AIChE, Nov 16-21, Atlanta, GA, AIChE. (National)

Greist, C., Song, L., Martin, L., Yan, Y., & Li, Y. (presented 2014, November). Undergraduate Research Forum: Proteomics analysis of extracellular matrix derived from pluripotent stem cell aggregates. Presentation at 2014 Annual Meeting of AIChE, Nov 16-21, Atlanta, GA, AIChE. (National)

Sart, S., Yan, Y., Ma, T., & Li, Y. (presented 2014, March). Extracellular Matrices derived from Pluripotent Stem Cell Aggregates for Tissue Development. Presentation at 4th International Conference on Stem Cell Engineering, March 16-19, Coronado, CA, 2014, SBE and ISSCR. (International)

Sart, S., Calixto Bejarano, F., Barid, M., Yan, Y., Rosenberg, J., Ma, T., Grant, S., & Li, Yan (presenter). (presented 2014, March). Intracellular Labeling of Pluripotent Stem Cell-derived Neural Progenitor Aggregates with Micron-sized Particles of Iron Oxide for Magnetic Resonance Imaging. Presentation at 4th International Conference on Stem Cell Engineering, March 16-19, Coronado, CA, 2014 (Oral), SBE and ISSCR. (International)

Yan, Y., Calixto Bejarano, F., Sart, S., Muroski, M., Strouse, G., Grant, S., & Li, Y. (presented 2014, January). Cryopreservation of Pluripotent Stem Cell-derived Neural Progenitor Aggregates Labelled with Micron-sized Particles of Iron Oxide. Presentation at Materials Retreat, Office of Research at Florida State University, Tallahassee, FL. (Local)

Sart, S., Yan, Y., Liu, Y., Ma, T., & Li, Y. (presented 2013, November). Microenvironment Regulation of Tissue Development from Pluripotent Stem Cells Post-cryopreservation. Presentation at 2013 Annual Meeting, American Institute of Chemical Engineers (AIChE), San Francisco, CA. (National)

Sart, S., Liu, Y., Ma, T., & Li, Y. (presented 2013, November). Tissue Development of Pluripotent Stem Cell-derived Neural Progenitor Aggregates Regulated by Human Mesenchymal Stem Cell Secretome. Presentation at 2013 Annual Meeting, American Institute of Chemical Engineers (AIChE), San Francisco, CA. (National)

Sart, S., Ma, T., & Li, Y. (presented 2013, March). Extracellular matrices decellularized from embryonic stem cells regulated the reseeded cell proliferation and differentiation. Presentation at Regenerative Medicine, Technologies Enabling Novel Therapies, 17th Annual Hilton Head Workshop, Hilton Head Island, SC. (Regional)

Sart, S., Ma, T., & Li, Y. (presented 2012, November). Characterization of acellular matrix derived from ESC aggregates as bioactive scaffolds. Presentation at 2012 Annual Meeting, American Institute of Chemical Engineers (AIChE), Pittsburg, PA. (National)

Sart, S., Ma, T., & Li, Y. (presented 2012, November). Size-dependent cryopreservation of pluripotent stem cell aggregates. Presentation at 2012 Annual Meeting, American Institute of Chemical Engineers (AIChE), Pittsburg, PA. (National)

Sart, S., Ma, T., & Li, Y. (presented 2012, September). Acellular matrices derived from PSC aggregates as bioactive scaffolds. Presentation at 4th Southeast Stem Cell Consortium Workshop, SouthEast Stem Cell Consortium (SESCC), Tallahassee, FL. (Regional)

Sart, S., Ma, T., & Li, Y. (presented 2012, September). Cryopreservation of pluripotent stem cell aggregates in defined protein-free formulation. Presentation at 4th Southeast Stem Cell Consortium Workshop, SouthEast Stem Cell Consortium (SESCC), Tallahassee, FL. (Regional)

Li, Y. (presented 2012, July). Introduction of current Good Manufacturing Practices (cGMP) to future process engineers. Poster presentation at 2012 ASEE Workshop, American Society for Engineering Education (ASEE), Orono, Maine. (National)

Xu, C., Police, S., Hassanipour, M., Li, Y., Yang, J., Brandenberger, R., Chen, Y., Priest, C., Chen, K., Zhu, W-Z., Laflamme, M., Murry, C., Davies, A., Lebkowski, J., & Gold, J. (presented 2009, August). Scalable and efficient cardiomyocyte differentiation from human embryonic stem cells. Presentation at 238th National Meeting, American Chemical Society (ACS), Washington, DC. (National)

Xu, C., Police, S., Rao, N., Hassanipour, M., Li, Y., Yang, J., Wang, W. B., Chen, Y., Priest, C., Chen, K., Zhu, W-Z., Laflamme, M., Murry, C., Davies, A., Lebkowski, J., & Gold, J. (presented 2008, August). Controlled cardiomyocyte differentiation from human embryonic stem cells for cell transplantation therapy. Presentation at 236th National Meeting, American Chemical Society (ACS), Philadelphia, PA. (National)

Xu, C., Police, S., Li, Y., Rao, N., Hassanipour, M., Yang, J., Wang, W. B., Davies, A., Lebkowski, J., & Gold, J. (presented 2007, June). Specific cardiomyocyte differentiation from human embryonic stem cells maintained in non-conditioned medium. Poster presentation at 5th Annual Meeting, International Society for Stem Cell Research (ISSCR), Cairns, Queensland, Australia. (International)

Xu, C., Police, S., Hassanipour, M., Li, Y., Prakash, K., Lebkowski, J., & Gold, J. (presented 2006, July). Human embryonic stem cells maintained in non-conditioned medium have capacity to differentiate into cardiomyocytes: progress toward the clinic. Poster presentation at 4th Annual Meeting, International Society for Stem Cell Research (ISSCR), Toronto, Ontario, Canada. (International)

Prakash, K., Li, Y., Denham, J., Brunette, E., Powell, S. E., Lee, G., Yeganeh, E., Yang, J., Yakusevich, P., Thies, S., Busch, M., Drake, S., & Lebkowski, J. (presented 2006, July). Large scale production of differentiated GRNOPC1 cells. Poster presentation at 4th Annual Meeting, International Society for Stem Cell Research (ISSCR), Toronto, Ontario, Canada. (International)

Brunette, E., Li, Y., Yeganeh, E., Powell, S. E., Rabbie, J., Hallock, T., Yakusevich, P., & Mandalam, R. (presented 2005, June). Production of human embryonic stem cell master cell bank for therapeutic use using serum-free non-conditioned medium. Poster presentation at 3rd Annual Meeting, International Society for Stem Cell Research (ISSCR), San Francisco, CA. (International)

Li, Y., Denham, J., Thies, S., Brunette, E., Majumdar, A. S., Fortin, J., Powell, S. E., Priest, C., Keirstead, H., Lebkowski, J., & Mandalam, R. (presented 2004, November). Scalable production of glial progenitor cells from human embryonic stem cells grown in defined animal component-free culture. Presentation at 2004 Annual Meeting, American Institute of Chemical Engineers (AIChE), Austin, TX. (National)

Powell, S. E., Brunette, E., Li, Y., Bronstein, A., Xu, C., Lebkowski, J., & Mandalam, R. K. (presented 2004, June). Conditioned medium produced with human cell lines and serum-free media supports undifferentiated human embryonic stem cell cultures. Poster presentation at 2nd Annual Meeting, International Society for Stem Cell Research (ISSCR), Boston, Massachusetts. (International)

Li, Y., Brunette, E., & Mandalam, R. (presented 2003, November). Expansion of human embryonic stem cells in defined serum-free medium free of animal-derived products. Presentation at 2003 Annual Meeting, American Institute of Chemical Engineers (AIChE), San Francisco, CA. (National)

Brunette, E., Li, Y., Powell, S., & Mandalam, R. (presented 2003, April). Qualification of hES cell line and production of hES cells for clinical application. Poster presentation at Keystone Symposia: From Stem Cells to Therapy, Keystone Symposia, Steamboat Springs, Colorado. (National)

Invited Lectures and Readings of Original Work

Li, Y. (2022, September). Engineering Human Stem Cell-derived Extracellular Vesicles for Treating Neurological Disorders. Delivered at Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH. (National)

Li, Y. (2022, June). Engineering Human Stem Cell-derived Extracellular Vesicles for Treating Neurological Disorders. Delivered at PBS Biotech Inc, Camarillo, CA. (National)

Li, Y. (2022, April). Engineering Human Stem Cell-derived Extracellular Vesicles for Treating Neurological Disorders. Delivered at College of Medicine, Florida State University, Tallahassee, FL. (Local)

Li, Y. (2021, November). Engineering Human Stem Cell-derived Extracellular Vesicles. Delivered at School of Pharmacy, University of North Carolina at Chapel Hill, Virtual. (National)

Li, Y. (2021, October). Three-dimensional multicellular aggregates derived from human stem cells. Delivered at Department of Chemical, Biological and Bio Engineering, North Carolina A&T State University, Virtual. (National)

Li, Y. (2021, September). Engineering Human Pluripotent Stem Cell-derived Brain Organoids for Studying Neurological Disorders. Delivered at School of Chemical and Biomolecular Engineering at Georgia Tech University, Atlanta, GA. (National)

Li, Y. (2021, September). Engineering Human Stem Cell-derived Brain Organoids for Treating Neurological Disorders. Delivered at Department of Biomedical Engineering, University of Connecticut, Virtual (Storrs, CT). (National)

Li, Y. (2021, July). Engineering extracellular vesicles secreted from human stem cells. Delivered at Institut Pasteur in Paris, France, Virtual. (International)

Li, Y. (2021, April). Human stem cell-derived brain organoids for drug screening. Delivered at Tech Topics event, Innovation Park of Tallahassee, Virtual. (Regional)

Li, Y. (2020, September). Biochemical and Biophysical Regulation of Human Pluripotent Stem Cell-derived Tissue Development. Delivered at Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama (Virtual). (National)

Li, Y. (2020, March). Engineering Human Pluripotent Stem Cell-Derived Organoids to Study Neural Degeneration. Delivered at North Carolina A&T State University, Greensboro, North Carolina. (National). (Cancelled due to COVID-19)

Li, Y. (2020, February). Human Pluripotent Stem Cell-based Biomanufacturing: Biochemical and Biophysical Regulations. Delivered at Department of Biomedical Engineering at Pennsylvania State University, State College, PA. (National)

Li, Y. (2019, September). Engineering Human Pluripotent Stem Cell-based or Cell-free Therapeutics. Delivered at Eli Lilly Company, Indianapolis, IN. (National)

Li, Y. (2019, July). Impacts of Biophysical Properties of Extracellular Matrices on Fate Decisions of Human Pluripotent Stem Cells. Delivered at Huazhong University of Science and Technology. (International)

Li, Y. (2019, July). The influence of extracellular microenvironment on human stem cell fate decisions. Delivered at Zhejiang University. (International)

Li, Y. (2018, July). Engineering and Characterization of Cortical Spheroids and Forebrain Organoids from Human Stem Cells. Delivered at China-Japan Friendship Hospital, Beijing, China. (International)

Li, Y. (2018, July). Engineering Forebrain Organoids from Human Stem Cells. Delivered at Hunan University of Technology, Zhuzhou, China. (International)

Li, Y. (2017, August). Engineering Mini-Brain Construct from Human Induced Pluripotent Stem Cells based on Biomaterials. Delivered at College of Chemical Engineering and Biological Engineering, Zhejiang University, China. (International)

Li, Y. (2016, February). Engineering Mini-Brain Construct from Human Induced Pluripotent Stem Cells. Delivered at 2016 FSU Life Sciences Symposium, Tallahassee, FL. (Regional)

Li, Y. (2015, March). Stem Cell-based Tissue Engineering. Delivered at Connecting Experimental Lab and Life Sciences (CELLS), Florida State University. (Local)

Li, Y. (2015, February). Niche engineering of pluripotent stem cells in three dimensions. Delivered at Dept of Chemical and Biomedical Engineering, Florida State University. (Local)

Li, Y. (2014, April). Neural differentiation of pluripotent stem cells and the intracellular labeling with superparamagnetic iron oxide nanoparticles. Delivered at College of Nanoscale Science and Engineering, State University of New York (SUNY) at Albany. (National)

Li, Y. (2013, April). Scalable Systems of Human Pluripotent Stem Cell (hPSC) Derived Therapeutics. Delivered at Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL. (National)

Li, Y. (2013, January). Human Pluripotent Stem Cell Therapies: from Research to Manufacturing. Delivered at Institute of Molecular Biophysics, Florida State University, Tallahassee, Fl. (Local)

Li, Y. (2012, November). Human Embryonic Stem Cell Derived Cell Therapies. Delivered at Society for Biological Engineering (SBE) chapter, Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH. (National)

Li, Y. (2012, October). Pluripotent Stem Cell Derived Cell Therapies. Delivered at Department of Mechanical Engineering, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL. (Local)

Li, Y. (2012, February). Development of Scalable Manufacturing Processes for Human Pluripotent Stem Cell (hPSC) Derived Therapeutics. Delivered at Biomedical Engineering Society (BMES) chapter, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL. (Local)

Patented Inventions

Li, Y., & Ma, T. (submitted). A Novel Method to Introduce Vascular Cells into Brain Organoids. US Patent Application, 62/821,807. 

Li, Y. (2019). Three-dimensional human stem cell-derived cortical spheroid model. US Patent 10,323,229. 

Li, Y., Teng, M., & Sart, S. (2018). Extracellular matrix derived from pluripotent stem cells and method for production. US Patent 10,035,980. 

Mandalam, R., Li, Y., & Nadeau, I. (2015). Suspension culture of human embryonic stem cells. US Patent, 9,074,181; UK Patent GB2441488; Canada Patent CA2613369; EPO Patent EP19105. 

Xu, C., Li, Y., & Mandalam, R. (2008). Medium for growing human embryonic stem cells. US Patent 7,455,983; UK Patent GB2431165; Canada Patent CA2573437; EPO Patent EP1809739. 

Contracts and Grants

Contracts and Grants Funded

Li, Yan (PI). (Jan 2023–Jun 2023). Supplemental Award 2: CAREER: Engineering Brain-region-specific Organoids Derived from Human Stem Cells. Funded by National Science Foundation. Total award $55,000. 

Li, Yan (PI). (Aug 2022–Jul 2025). Multifunctional 3D Bioelectronic and Microfluidic Hybrid Systems for Online Monitoring, Regulation, and Vascularization of Brain Organoids. Funded by University of Connecticut (Primary NIH, $643,591). Total award $135,000. 

Li, Yan (PI). (May 2022–Nov 2022). Supplemental Award: CAREER: Engineering Brain-region-specific Organoids Derived from Human Stem Cells. Funded by National Science Foundation. Total award $54,995. 

Li, Yan (co-PI), Olcese, James (PI), & Sun, Li (co-PI). (Apr 2022–Apr 2023). Mesenchymal Stem Cell-Derived Extracellular Vesicles for the Treatment of Alzheimer's Disease. Funded by Florida Department of Health. Total award $30,000. 

Li, Yan (PI), Grant, Sam (Co-PI), Zhou, Yi (Co-I), & Driscoll, Tristan (Co-I). (Mar 2022–Feb 2027). Engineering Extracellular Vesicles of Human Brain Organoids for Stroke Therapy. Funded by National Institutes of Health (R01 NS125016). Total award $1,825,992. 

Li, Yan (PI). (Sep 2021–Aug 2024). Excellence in Research: Human stem cell-derived polarized dorsoventral forebrain organoid: effect of matrix stiffness and mechanical stimulus. Funded by North Carolina A&T University (primary: NSF 2100987, $489,765). Total award $80,000. 

Li, Yan (PI). (Jul 2021–Jun 2022). DSA: Developing Scholar Award. Human Stem Cell-based Disease Modeling and Drug Screening. Funded by Florida State University. Total award $10,000. 

Li, Yan (co-PI), Sang, Qing-Xiang (PI), & Ren, Yi (Co-PI). (May 2021–May 2024). Modeling Human Pediatric Brain Tumor Microenvironment. Funded by Florida Department of Health. Total award $246,510. 

Yun, Yeoheung (PI), & Li, Yan (collaborator). (Feb 2021–Jan 2025). Alzheimer's disease-replicated brain microphysiological system to model AD physiopathology and its influence on gliovasculature and immune system (1%). Funded by North Carolina A&T University, National Institutes of Health (SC1GM135139). Total award $1,434,603. 

Li, Yan (PI). (Jan 2021–Jun 2021). Supplemental Award: Maintaining Energy Homeostasis to Preserve Biological Properties during Culture Expansion of Human Mesenchymal Stem Cells. Funded by National Science Foundation (1934047). Total award $54,999. 

Grant, Sam (PI), Li, Yan (co-PI), Guan, Jingjiao (Co-PI), Ali, Jamal (co-PI), Holmes, Christina (co-PI), & Meckes, David (co-PI). (May 2020–May 2021). EIEG: Biochemical Analyzer for Cell Culture Facilities. Funded by Florida State University. Total award $34,174. 

Li, Yan (PI), & Zeng, Changchun (co-PI). (Jan 2020–Dec 2023). Human Stem Cell Fate decisions dictated by decoupled biophysical cues. Funded by National Science Foundation (1917618). Total award $400,000. 

Guan, J. (PI), & Li, Yan (co-PI). (Jul 2019–Oct 2019). In vitro validation of a microdevice-based drug delivery system for treating solid tumors. Funded by Institute for Successful Longevity (ISL) Planning Grant, Florida State University. Total award $15,500. 

Li, Yan (PI), & Logan, Timothy M (Co-PI). (May 2019–Jul 2022). Collaborative Research: Maintaining Energy Homeostasis to Preserve Biological Properties during Culture Expansion of Human Mesenchymal Stem Cells. Funded by National Science Foundation (1743426). Total award $342,308. 

Grant, Sam (PI), & Li, Yan (co-I). (May 2019–Apr 2023). MR Analysis of Pre-Conditioned Human Mesenchymal Stem Cells for Stroke Therapy. Funded by National Institutes of Health. (R01NS102395). Total award $417,648. 

Li, Y. (co-PI), & Sang, Qing-Xiang Amy (PI). (Apr 2019–Mar 2022). Engineering Human Childhood Brain Malignant Rhabdoid Tumor Organoids. Funded by Florida Department of Health. Total award $250,000. 

Li, Y. (PI), & Song, L. (May 2018–May 2018). Heterotypic cell-cell interactions of human stem cells for neural differentiation of hybrid spheroids. Funded by Engineering Conference International-Cell Culture Engineering XVI Travel Grant Program. Total award $2,030. 

Li, Yan (PI), & Zhou, Yi (co-PI). (Aug 2017–Jul 2020). Engineering Extracellular Matrices in Forebrain Organoids for Studying Neural Degeneration. Funded by National Institutes of Health. Total award $142,613. 

Li, Yan (PI). (Apr 2017–Mar 2024). CAREER: Engineering Brain-region-specific Organoids Derived from Human Stem Cells. Funded by National Science Foundation. (1652992). Total award $501,345. 

Li, Yan (PI), & Ma, Teng (co-PI). (Sep 2016–Jul 2018). Heterotypic Cell-Cell Interactions in Hybrid Human Stem Cell Microtissues during Neural Differentiation. Funded by National Institutes of Health. Total award $140,768. 

Li, Y. (PI). (Aug 2016–Jul 2017). Engineering Human Cortical Organoids derived from Induced Pluripotent Stem Cells. Funded by Florida State University Bridge Grant. Total award $25,000. 

Zhou, Huan-Xiang (PI), Li, Yan (Co-PI), & Others. (May 2016–May 2017). Acquisition of a Microscale Thermophoresis Instrument for Binding Affinity Measurements. Funded by Florida State Univerisity, EIEG. Total award $60,000. 

Li, Y. (PI), & Yan, Y. (May 2016–May 2016). Neural patterning of human induced pluripotent stem cells for studying neurotoxicity. Funded by Engineering Conference International-Cell Culture Engineering XV Travel Grant Program. Total award $5,405. 

Wang, Yanchang (PI), Li, Yan (Co-PI), & Others. (Jan 2015–Jan 2016). Enhancing Biomedical Research by Confocal Microscopy with Quantitative Capability. Funded by FSU, Equipment and Infrastructure Enhancement Grant. Total award $85,000. 

Li, Y. (PI). (Jan 2015–Jan 2015). Acellular Matrices Derived from Pluripotent Stem Cells Modulate Tissue Development. Funded by Scale-Up and Manufacturing of Cell-Based Therapies IV, Engineering Conference International Travel. Total award $2,400. 

Li, Y. (2015–2015). Travel: 2015 NSF CAREER writing workshop, Boston, MA. Funded by FSU CRC FAT program. Total award $1,000. 

Li, Yan (PI). (Dec 2014–May 2016). Constructing Cardiac Tissues Using 3-D Auxetic Scaffolds. Funded by Florida State University CRC, Planning Grant. Total award $13,000. 

Meckes, David (PI), Li, Yan (Co-PI), & Others. (Jul 2014–Jul 2015). Enhancing Cell Biology Research Through Automated Cell Counting and Fluorescent-Based Cell Assays. Funded by Florida State University. Total award $30,000. 

Li, Yan (PI). (May 2014–Dec 2014). Biomechanical Regulation of Neural Differentiation from Pluripotent Stem Cells. Funded by Florida State University, Faculty Research Support Grant. Total award $14,000. 

Li, Y. (2014–2014). Travel: NSF grant conference meeting, Denver, CO, June 2014. Funded by FSU CRC FAT program. Total award $1,000. 

Li, Yan (PI). (Oct 2013–Sep 2017). BRIGE: Engineering a BioMatrix Library Derived from Induced Pluripotent Stem Cells. Funded by National Science Foundation. (Award 1342192). Total award $174,737. 

Li, Yan (PI), & Ma, T. (May 2013–Nov 2014). Rapid Drug Discovery Using Living Tissue Test Environments. Funded by FSU Research Foundation GAP Program. Total award $43,000. 

Olcese, James (PI), Li, Yan (Co-PI), & others. (Jan 2013–Dec 2013). Improving Time and Resource Efficiency with Capillary Nanofluidic Protein Detection. Funded by Florida State University, Equipment and Infrastructure Enhancement Grant (EIEG). Total award $40,000. 

Li, Yan (PI), Chella, R., & Ma, T. (Jun 2012–May 2014). Introduction to current good manufacturing practices (cGMP) for future process engineers. Funded by Florida State University, Student Technology Committee. Total award $32,009. 

Li, Yan (PI). (May 2012–Aug 2012). Scalable cryopreservation and thaw bioprocess for human pluripotent stem cell derived cell therapy. Funded by Florida State University, FYAP. Total award $17,000. 

Postdoctoral Supervision

Khamis, Z. (Aug 2022–present). 

Sun, Li (Research Faculty I) (Apr 2022–present). 

Yuan, Xuegang (a Toffler neuroscience scholar) (2019–21). 

Henderson, Elizabeth (Provost Postdoctoral Fellow) (2019–20). 

Fu, Q. (May–Aug 2019). 

Sart, S. (2012–13). 

Reviews of My Research and Original Creative Work by Other Authors

Reviews Appearing in Magazines or Newsletters

FSU FDA. (2017, February). 2017 Faculty Award Winners. FDA Newsletter, 2, 1. 

Reviews Appearing on a Web Site

Wellock, B. (2022). $1.8M NIH grant to fund new treatment for stroke patients. Florida State University News. 

Bill Edmonds. (2021). ISL Faculty Affiliate Yan Li receives Developing Scholar Award. The Institute for Successful Longevity. 

Trisha Radulovich. (2021). Postdoc Spotlight: Xuegang Yuan, Ph.D. FAMU-FSU College of Engineering News. 

Radulovich, T. (2020). Five FAMU-FSU Engineering students land prestigious NSF Fellowships. FAMU-FSU College of Engineering News. 

Wellock, B. (2019). High-tech foam offers new tool for developing stem cells. Florida State University News. 

Engineering News. (2017). Research collaborations blossom between the FAMU-FSU College of Engineering and the FSU College of Medicine. FAMU-FSU College of Engineering News. 

Engineering News. (2017). FAMU-FSU chemical engineering professor receives NSF CAREER Award. FAMU-FSU College of Engineering News. 

Haughney, K. (2014). INNOVATORS RECEPTION - University honors top inventors, researchers for new work. FAMU-FSU College of Engineering News. 

Service

The goal of my services is to: (1) impact the programs of our department, college, and university; (2) impact the general community and K-12 outreach activities; (3) impact the professional societies and scientific communities. 

Florida State University

FSU University Service

Evaluation Committee, Pew Biomedical Scholars Limited Submissions program (2022–present).

Member, Goldwater Student Selection Committee, the Office of national Fellowships (2020–present).

Panelist, NSF CAREER Workshop (2018–2019).

Reviewer, the Committee on Faculty Research Support (COFRS) Grant review panel (2016–2017).

FSU College Service

Panelist of Mock Review for NSF CAREER proposal, NSF CAREER- Engineering initiative (2019–2022).

FSU Department Service

Director/Coordinator, Department Postdoc Program (2022–present).

Director, Honors in The Major/URP/UROP Program (2020–present).

Member/Chair, Junior Faculty Mentoring Committee (2020–present).

Member, Biomedical Engineering Program Committee (2017–present).

Reviewer, ABET Outcome Assessment Team (2012–present).

Faculty Advisor, Undergraduate Academic Advising (2012–present).

Chair, PhD Qualifier Exam Committee (BME) (2019–2022).

Member, Search committee, Tenure track professor in biomedical engineering (2019–2020).

Member, Undergraduate Committee (2012–2020).

Member, PhD Qualifier Exam Committee (ECH) (2018).

Member, Search committee, Tenure track assistant professor in biomedical engineering (2017–2018).

Member, Ph.D. Qualifier Exam Committee (ECH) (2015–2016).

Interim Faculty Advisor, National Society of Black Engineers, Biomedical Engineering Society, local student chapters (2015).

Assistance in coordinating corporate contributions and involvement, Development committee for the new Institute of Cellular Engineering and Molecular Imaging (2011–2012).

FSU Program Service

Reviewer and editing for new BME courses, New BME BS program (2018–present).

The Profession

Editorial Board Membership(s)

Biomolecules (2022–present).

Frontiers in Chemical Engineering, Associate Editor in Biochemical Engineering (2021–present).

Recent Patents on Biotechnology (2013–2020).

International Journal of Stem Cell Research and Transplantation (IJST) (2013–2018).

Pharmaceutical Bioprocessing (2013–2015).

Guest Reviewer for Refereed Journals

ACS Nano (IF: 18.027) (2022–present).

Cytotherapy (2022–present).

Advanced Healthcare Materials (IF: 10.26) (2021–present).

Chemical Engineering Journal (IF:16.744) (2021–present).

Biomaterials Science (IF: 6.183) (2020–present).

Cancers (IF: 6.162) (2020–present).

Cell Stem Cell (IF: 24.633) (2020–present).

Journal of Hazardous Materials (IF: 14.224) (2020–present).

Small (IF: 15.153) (2020–present).

Advanced Science (IF:17.521) (2019–present).

Bioactive Materials (IF: 16.867) (2019–present).

Cells (IF: 7.7) (2019–present).

Emerging Microbes & Infections (IF: 6.212) (2019–present).

Macromolecular Bioscience (IF: 3.85) (2019–present).

Scientific Reports (IF: 4.999) (2019–present).

Stem Cells International (IF: 5.443) (2019–present).

Theranostics (IF: 11.556) (2019–present).

ACS Applied Bio Materials (IF: 5.0-7.5) (2018–present).

FEBS Letters (IF: 3.0) (2018–present).

iScience (2018–present).

Journal of Advanced Research (2018–present).

Journal of Cellular Biochemistry (IF: 3.085) (2018–present).

Molecular Immunology (IF: 3.188) (2018–present).

ACS Biomaterials Science & Engineering (IF: 4.511) (2017–present).

Journal of Biomedical Materials Research: Part B - Applied Biomaterials (2017–present).

BMC Cell Biology (2016–present).

Experimental & Molecular Medicine (IF: 5.063) (2016–present).

Molecular Pharmaceutics (IF: 4.556) (2016–present).

Biochemical Engineering Journal (IF: 4.446) (2015–present).

Journal of Tissue Engineering and Regenerative Medicine (IF: 4.089) (2015–present).

PLOS ONE (2015–present).

Stem Cell Research & Therapy (IF: 8.06) (2015–present).

ACS Applied Materials & Interfaces (IF: 10.383) (2014–present).

Acta Biomaterialia (IF: 10.633) (2014–present).

BioReseacrh Open Access (2014–present).

Bioresource Technology (IF: 11.889) (2014–present).

Biotechnology Journal (IF: 4.677) (2014–present).

Cancer Letters (IF: 8.679) (2014–present).

Differentiation (IF: 2.567) (2014–present).

Processes (IF: 2.973) (2014–present).

Biotechnology and Bioengineering (IF: 4.53) (2013–present).

Cytotechnology (2013–present).

Journal of Materials Chemistry B (IF: 4.872) (2012–present).

Nano LIFE (2012–present).

Stem Cells and Development (IF: 3.315) (2012–present).

Biomaterials (IF: 15.304) (2006–present).

Tissue Engineering (IF: 7.376) (2004–present).

Biotechnology Progress (IF: 2.167) (2002–present).

Process Biochemistry (IF: 4.885) (2002–present).

Reviewer for Textbooks

Preservation of Cells: a Practical Manual (2014).

Chair of a Symposium

Li, Y. (Chair). (2020, November). 2020 AIChE Annual meeting: Materials Engineering & Sciences (08B Biomaterial Scaffolds for Tissue Engineering). Symposium conducted at the meeting of AIChE, San Francisco, CA. 

Li, Y. (Chair). (2019, November). 2019 AIChE Annual Meeting, Food, Pharmaceutical & Bioengineering Division (15), poster session, Nov 10-15, 2019. Symposium conducted at the meeting of AIChE, Orlando, FL. 

Li, Y. (Chair). (2018, October). 2018 Biomedical Engineering Society (BMES) Annual meeting, Session- Stem Cells in Tissue Engineering, Oct 17-20, 2018. Symposium conducted at the meeting of BMES, Atlanta, GA. 

Li, Y. (Chair). (2017, October). 2017 AIChE Annual meeting: Materials Engineering & Sciences (08B Biomaterial Scaffolds for Tissue Engineering), Oct 29-Nov 03, 2017. Symposium conducted at the meeting of AIChE, Minneapolis, MN. 

Li, Y. (Chair). (2016, November). 2016 AIChE Annual meeting: Materials Engineering & Sciences (08B-Biomaterials for in Vitro Tissue Models and Improved Therapeutic Strategies), Nov 13-18, 2016. Symposium conducted at the meeting of AIChE, San Francisco, CA. 

Li, Y. (Chair). (2016, October). 2016 Biomedical Engineering Society (BMES) Annual meeting, Session- Dynamic Biomaterials, Oct 5-8, 2016. Symposium conducted at the meeting of Biomedical Engineering Society (BMES), Minneapolis, MN. 

Li, Y. (Chair). (2016, May). ECI Cell Culture Engineering Conference XV: poster session. May 8-13, 2016. Symposium conducted at the meeting of Engineering Conferences International (ECI), La Quinta, CA. 

Li, Y. (Chair). (2015, November). 2015 AIChE Annual meeting: Materials Engineering & Sciences (08B - Biomaterials). Nov 8-13, 2015. Symposium conducted at the meeting of AIChE, Salt Lake City, UT. 

Li, Y. (Chair). (2015, January). Scale-Up and Manufacturing of Cell-Based Therapies IV: Scale-out, scale-up. Jan 18-22, 2015. Symposium conducted at the meeting of Engineering Conferences International (ECI), San Diego, CA. 

Reviewer or Panelist for Grant Applications

Austrian Academy of Sciences (2020–present).

Dutch Research Council, The Netherlands (2020–present).

INSTITUT PASTEUR, France (2020–present).

United Kingdom Motor Neurone Disease Association (2020–present).

European Science Foundation (2019–present).

Indiana Alzheimer Disease Center (2019–present).

Human Frontier Science Program Organization (2018–present).

National Institutes of Health (USA) (2017–present).

National Science Foundation (USA) (2015–present).

UK Regenerative Medicine Platform (UKRMP), 2013, 2017 (2013–present).

Service to Professional Associations

Abstract reviewer for annual meeting, Biomedical Engineering Society (2016–present).

Member, Facilitated Dr. David Gilbert (FSU Department of Biological Science) on the organization of 4th Southeast Stem Cell Consortium Workshop, Southeast Stem Cell Consortium (2012).

The Community

College of Engineering Representative, FSU Chinese Professor Association (2021–present).

Laboratory tour to junior women students, Women in Math, Science & Engineering (WIMSE) (2016–present).

Judge, Capital Regional Science and Engineering Fair (2022).

Organizer and presenter, Outreach to general public: demonstration and biomedical engineering lab tour, College of Engineering Open House (2020).

Mentor for middle school and high school girls, MagLab Speed Mentoring Event, 2019 United Nations International Day of Women and Girls in Science (2019).

Judge, Capital Regional Science and Engineering Fair (2019).

Judge, Capital Regional Science and Engineering Fair (2018).

Lecturer, Science, Technology, Engineering, Art and Mathematics (STEAM) day, Leon County School (2016).

Mentor, Ladies Learning to Lead "L3" for middle school and high school girls (2014).

Panelist, SciGirls Summer Camp, National High Magnetic Field Laboratory (NHMFL) and WFSU (2013).

Panelist, Advancement of Florida's Academic Women in Chemistry and Engineering (AAFAWCE) (2013).

Member, Nominated as FSU representative, Alliance for the Advancement of Florida's Academic Women in Chemistry and Engineering (AAFAWCE) (2012–2013).

Lecturer, Family Literacy Program for the Leon County Public Library system (2012).

Lecturer, "Outreach Program" to educate Wakulla Spring high school students (2012).